Evaluation of effect of Atorvastatin gel on treatment of periodontal inflammatory disease

Phase 3

Conditions: chronic periodontitis.
Chronic periodontitis
K05.3

Registration Number: IRCT20150210021029N4

Lead Sponsor: Esfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 20

Inclusion Criteria

Having mild to moderate chronic periodontitis (bone crest distance from CEJ>2, Clinical Attachment Loss=3)
Having at least 20 teeth
Not having bridge, crown or orthodontic braces in gel application area
Having at least 2 pockets with 4-7mm of probing depth and CAL of equal to or greater than 3mm
Having general health

Exclusion Criteria

Having systemic diseases
Pregnancy and lactation
Receiving periodontal treatment and/or usage of antibiotics during 1 month before treatment
Presence of aggressive periodontitis and systemic conditions affecting the periodontal condition
Malnutrition and impaired immune status
Smoking
Using statins or allergy to them
Presence of symptoms of corona virus disease or similar symptoms
Using drugs that affect oral tissues
Use of antibiotics
Use of cholesterol-lowering drugs such as statins

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pocket Depth. Timepoint: At baseline (before the intervention) and at 6 weeks and 3 months after gel application. Method of measurement: Williams Periodontal Probe (Hu-Friedy®, USA).;Clinical Attachment Level. Timepoint: At baseline (before the intervention) and at 6 weeks and 3 months after gel application. Method of measurement: Williams Periodontal Probe (Hu-Friedy®, USA).;Modified Sulcular Bleeding Index. Timepoint: At baseline (before the intervention) and at 6 weeks and 3 months after gel application. Method of measurement: Williams Periodontal Probe (Hu-Friedy®, USA).

Secondary Outcome Measures