Efficacy Evaluation of Wasabi (Wasabia Japonica) Leaf Extract on Skin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- The change of transepidermal water loss
研究概览
简要总结
To assess the efficacy of Wasabi Leaf Extract on skin
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20 to 65-year-old males or females
- •People with dull skin, pigmentation spots or acne-prone, acne scars
- •Acne severity assessment- Investigator's Global Assessment Scale (IGA) ≥ 2
排除标准
- •Received medical cosmetic treatment (including cosmetic skin care, laser, fruit acid peeling, injection or plastic surgery, etc.) currently or within one month before the trial
- •Outdoor workers (exposed to the sun more than 5 hours a day)
- •People who are breastfeeding, pregnant or planning to become pregnant during the test (self-report)
- •People with heart, liver, kidney, endocrine and other major organic diseases (self-reported)
- •People who have undergone major surgery (according to medical history)
- •People who take drugs for a long time
- •People with mental illness
- •Students who are currently taking courses taught by the principal investigator of this trial
结局指标
主要结局
The change of transepidermal water loss
时间窗: Change from Baseline TEWL at 8 weeks
Tewameter® TM300 was utilized to measure transepidermal water loss (TEWL). Units: TEWL-values lower than 70 g/hm²
The change of skin sebum content
时间窗: Change from Baseline skin sebum content at 8 weeks
Sebumeter® SM815 was utilized to measure skin sebum content. Units: Sebumeter® units from 0-350
The change of skin erythema index
时间窗: Change from Baseline skin erythema index at 8 weeks
Mexameter® MX18 was utilized to measure skin erythema index. Units: arbitrary Mexameter® units (0-999)
The change of skin melanin index
时间窗: Change from Baseline skin melanin index at 8 weeks
Mexameter® MX18 was utilized to measure skin melanin index. Units: arbitrary Mexameter® units (0-999)
The change of a* (redness) values
时间窗: Change from Baseline a* value at 8 weeks
Spectrophotometer SCM-108 was utilized to measure skin a\* value. Units: arbitrary units
The change of skin red area
时间窗: Change from Baseline skin red area at 8 weeks
VISIA Complexion Analysis System was utilized to measure skin red area. Units: arbitrary units
The change of total antioxidant capacity of blood
时间窗: Change from Baseline total antioxidant capacity at 8 weeks
Venous blood was sampled to measure total antioxidant capacity
The change of Interleukin-8 of blood
时间窗: Change from Baseline IL-8 at 8 weeks
Venous blood was sampled to measure IL-8
The change of Interleukin-6 of blood
时间窗: Change from Baseline IL-6 at 8 weeks
Venous blood was sampled to measure IL-6
The change of Insulin-Like Growth Factor-1 of blood
时间窗: Change from Baseline IGF-1 at 8 weeks
Venous blood was sampled to measure IGF-1
The change of L* (lightness) values
时间窗: Change from Baseline L* value at 8 weeks
Spectrophotometer SCM-108 was utilized to measure skin L\* value. Units: arbitrary units
The change of visible spots
时间窗: Change from Baseline visible spots at 8 weeks
VISIA Complexion Analysis System was utilized to measure skin spots. Units: arbitrary units
次要结局
- The change of fasting blood glugose level(Change from Baseline fasting blood glugose level at 8 weeks)
- The change of renal function biomarkers (creatinine, BUN) of blood(Change from Baseline renal function biomarkers at 8 weeks)
- The change of Advanced glycation end products of blood(Change from Baseline AGEs at 8 weeks)
- The change of UV spots(Change from Baseline UV spots at 8 weeks)
- The change of blood lipid profile(Change from Baseline blood lipid profile at 8 weeks)
- The change of skin hydration(Change from Baseline skin hydration at 8 weeks)
- The change of brown spots(Change from Baseline brown spots at 8 weeks)
- The change of liver function biomarkers (AST, ALT) of blood(Change from Baseline liver function biomarkers at 8 weeks)