A Protocol for a Randomized, Two-Parallel-group Study to Compare the Efficacy of Testing LH Surge at Home Versus Medically Triggered Ovulation With hCG (Pregnyl®) in the Naturally Stimulated Cycle in the Frozen-thawed Embryo Transfer
Overview
- Phase
- Phase 4
- Intervention
- Human chorionic gonadotropin
- Conditions
- Infertility
- Sponsor
- Tampere University Hospital
- Enrollment
- 62
- Locations
- 1
- Primary Endpoint
- Live birth rate
- Status
- Terminated
- Last Updated
- last year
Overview
Brief Summary
The primary aim of this study is to find out if ovulation triggered with hCG provides any additional benefit in comparison to spontaneous LH surge measured with the LH surge home test when transferring frozen-thawed embryo in a natural cycle.
Detailed Description
The aim of this study is to find out the best method for the ovulation triggering. We study the live birth rates in the both groups.
Investigators
Eligibility Criteria
Inclusion Criteria
- •- Patient with IVF or ICSI cycle and therefore having frozen-thawed embryos
- •Regular menstruation cycle
- •Patient's willingness to participate in the study
Exclusion Criteria
- •- Irregular menstrual cycle demanding preparing endometrium with hormones for frozen-thawed embryo
- •No frozen embryos after IVF cycle
- •Allergy to Pregnyl® or some of its ingredients in the medication or other contraindications due to Pregnyl®
Arms & Interventions
Pregnyl (Human chorionic gonadotropin)
In this group, patients have natural cycle in frozen-thawed embryo transfer and the ovulation is confirmed by administration of hCG (Pregnyl® 5000 IU). The day of transferring embryo is depending on the day of administration of hCG and the age of the embryo. The day zero day is defined by ovulation triggered by hCG.
Intervention: Human chorionic gonadotropin
Home ovulation test
The patients randomized to the LH surge group perform the ovulation home test daily from the urine. Thus, the ovulation in this group is corfimed by the urine test. The day of transferring embryo is depending on the positive ovulation test and the age of the embryo. The day zero day is defined by positive ovulation test.
Intervention: Home ovulation test
Outcomes
Primary Outcomes
Live birth rate
Time Frame: At possible delivery (about 40 weeks)
Live birth rate
Secondary Outcomes
- Ongoing pregnancy rate(After two weeks)