ipid mediators of ultraviolet radiation (UVR) induced skin inflammatio

Not Applicable

Completed

• Conditions: Topic: Skin; Subtopic: Skin (all Subtopics); Disease: Dermatology; Skin and Connective Tissue Diseases; Acute skin changes due to ultraviolet radiation

• Registration Number: ISRCTN47896115
• Lead Sponsor: niversity of Manchester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10-20
• Last Update Posted: 20 February 2017

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 125

Inclusion Criteria

1. Healthy, human volunteers and patients with defined photosensitivity conditions.
2. Aged 18 - 60 years
3. Sun reactive skin type I - IV (white Caucasian)
4. Both male & female participants

Exclusion Criteria

1. History of skin cancer
2. Taking photoactive or anti-inflammatory medication
3. Sunbathing, sunbed use or phototherapy in the past 3 months
4. Taking nutritional supplements containing polyunsaturated fatty acids (PUFA)
5. Consuming more than 2 portions of oily fish per week
6. Pregnancy
7. Unable to eat fish or gelatine

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Concentration of bioactive lipids in skin samples following UVR exposure measured at 3 months

Secondary Outcome Measures

Name	Time	Method
1. Number of infiltrating inflammatory/immune cells during and until resolution of UVR induced inflammation measured at 3 months<br>2. The expression of key bioactive lipid metabolising enzymes and receptors in human skin measured at 3 months