Cognitive dysfunction and developmental risks for severe psychopathology: insights from sex chromosomal disorders - Neurodevelopmental risks in sex chromosomal disorders

niversiteit Leiden0 个研究点目标入组 200 人开始时间: 待定最近更新: 2024年5月6日

适应症

试验速览

暂无简介。

•General inclusion criteria include age between 4 and 12 (for the fMRI study: age between 9 and 12), voluntary participation, Dutch speaking and signed informed consent from parents. The specific inclusion criteria for the four groups are as following:;Klinefelter syndrome: diagnosed with (non-mosaic) Klinefelter syndrome based on the presence of a 47,XXY chromosomal pattern as determined by karyotyping.
•Turner syndrome: diagnosed with (non-mosaic) Turner syndrome based on the presence of a 46,XO chromosomal pattern as determined by karyotyping.
•Autism spectrum condition: an autism spectrum diagnosis according to DSM-IV or ICD-10 criteria
•Non-clinical controls: n/a

•Clinical groups:
•- history of closed-head injury or neurological illness
•- contraindications for MRI (part 2 study)
•- premature birth;Non-clinical groups:
•- use of psychotropic medication
•- history of psychiatric illness, closed-head injury, neurological illness or endocrinological dysfunction
•- contraindications for fMRI
•- premature birth

发起方

niversiteit Leiden