Cognitive dysfunction and developmental risks for severe psychopathology: insights from sex chromosomal disorders
- Conditions
- 1008362410012562sex chromosomal aneuploidysex chromosomal disorder
- Registration Number
- NL-OMON32524
- Lead Sponsor
- niversiteit Leiden
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 200
General inclusion criteria include age between 4 and 12 (for the fMRI study: age between 9 and 12), voluntary participation, Dutch speaking and signed informed consent from parents. The specific inclusion criteria for the four groups are as following:;Klinefelter syndrome: diagnosed with (non-mosaic) Klinefelter syndrome based on the presence of a 47,XXY chromosomal pattern as determined by karyotyping.
Turner syndrome: diagnosed with (non-mosaic) Turner syndrome based on the presence of a 46,XO chromosomal pattern as determined by karyotyping.
Autism spectrum condition: an autism spectrum diagnosis according to DSM-IV or ICD-10 criteria
Non-clinical controls: n/a
Clinical groups:
- history of closed-head injury or neurological illness
- contraindications for MRI (part 2 study)
- premature birth;Non-clinical groups:
- use of psychotropic medication
- history of psychiatric illness, closed-head injury, neurological illness or endocrinological dysfunction
- contraindications for fMRI
- premature birth
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>cognitive dysfunctions in relation to social behavioural difficulties,<br /><br>differences between the groups in BOLD (blood oxygen level dependent) response<br /><br>during cognitive tasks and FA (Fractional Anisotropy) as measured with MRI,<br /><br>levels of testosterone as measured in saliva samples.</p><br>
- Secondary Outcome Measures
Name Time Method <p>number of adverse events</p><br>