NL-OMON32524
Completed
N/A
Cognitive dysfunction and developmental risks for severe psychopathology: insights from sex chromosomal disorders - Neurodevelopmental risks in sex chromosomal disorders
niversiteit Leiden0 sites200 target enrollmentTBD
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- sex chromosomal aneuploidy
- Sponsor
- niversiteit Leiden
- Enrollment
- 200
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •General inclusion criteria include age between 4 and 12 (for the fMRI study: age between 9 and 12\), voluntary participation, Dutch speaking and signed informed consent from parents. The specific inclusion criteria for the four groups are as following:;Klinefelter syndrome: diagnosed with (non\-mosaic) Klinefelter syndrome based on the presence of a 47,XXY chromosomal pattern as determined by karyotyping.
- •Turner syndrome: diagnosed with (non\-mosaic) Turner syndrome based on the presence of a 46,XO chromosomal pattern as determined by karyotyping.
- •Autism spectrum condition: an autism spectrum diagnosis according to DSM\-IV or ICD\-10 criteria
- •Non\-clinical controls: n/a
Exclusion Criteria
- •Clinical groups:
- •\- history of closed\-head injury or neurological illness
- •\- contraindications for MRI (part 2 study)
- •\- premature birth;Non\-clinical groups:
- •\- use of psychotropic medication
- •\- history of psychiatric illness, closed\-head injury, neurological illness or endocrinological dysfunction
- •\- contraindications for fMRI
- •\- premature birth
Outcomes
Primary Outcomes
Not specified
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