Evaluation of coagulation effects of tranexamic acid in patients undergoing surgery for cerebral supratentorial tumors

Phase 2

Recruiting

• Conditions: supratentorial brain tumor.; D33.0; Benign neoplasm of brain, supratentorial

• Registration Number: IRCT20190202042588N3
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 November 2022

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

All surgeries for supratentorial tumors
Age over 16 years
Discontinue drugs that cause coagulation disorders
Women in non-pregnant status

Exclusion Criteria

history of coagulation disorders
history of gastrointestinal disease
history of liver disease
history of heart disease
history of renal failure (creatinine clearance less than 70min / mL, oliguria or dialysis 28 days before surgery)
history of diabetes
history of hypersensitivity disorders to ibuprofen, aspirin, nonsteroidal anti-inflammatory drugs, COX-2 inhibitors
history of asthma
long-term use of anticonvulsant drugs
smoking

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Hematocrit. Timepoint: Before surgery and one day after surgery. Method of measurement: Blood sampling.;Bleeding volume. Timepoint: during surgery. Method of measurement: Direct and visual measurement.