The effect of exercise at high altitude on thrombin generation in whole blood and ATP release from platelets

Completed

• Conditions: hypercoagulability - coagulation disorder; 10064477

• Registration Number: NL-OMON49175
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 12

Inclusion Criteria

* Healthy
* Age between 18 and 50 years old

Exclusion Criteria

* Previous history of cardiovascular disease, pulmonary disease, bleeding
disorder or venous thromboembolism
* Medication interfering with blood coagulation (low molecular weight heparins,
vitamin K antagonists, direct oral anticoagulants, non-steroidal
anti-inflammatory drugs)
* Impaired mobility
* Active smoking
* Not passing medical assessment (see section 3)
* Disapproval of contacting general practitioner in case of abnormalities found
during medical assessment or during the study

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>ATP release from platelets and thrombin generation in whole blood.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Thrombin generation in platelet poor plasma, platelet function test in whole<br /><br>blood, blood count and vital signs (oxygen saturation, heart rate and blood<br /><br>pressure).</p><br>