The effect of clonidine on desflurane consumption using BIS monitoring.

Phase 1

• Conditions: Depth of anaesthesia.Consumption of volatile anaesthetic agent.; MedDRA version: 8.1Level: LLTClassification code 10018060Term: General anaesthesia

• Registration Number: EUCTR2006-003139-65-GB
• Lead Sponsor: Medway NHS Trust

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2006-09-18
• Last Update Posted: 27 July 2020

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Patients having a general anaesthetic for a general surgical or orthopaedic procedure.
The surgical procedure should last no longer than 2 hours.
Aged between 18 and 70 years.
ASA grading as 1 or 2.
Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Age < 18 years or more > 70 years.
Beta blocker treatment.
ASA grading of > 2.
Raynaud's syndrome.
Peripheral vascular disease.
Depression.
Hypersensitivity to clonidine.
Sick sinus syndrome.
AV block.
Bradycardia < 50/min at rest.
Congestive heart failure.
Acute myocardial infarction in the past.
Pregnancy.
Breast feeding.
Systolic BP < 100 mmHg.
Renal or hepatic disease.
Patient taking medication known to alter MAC of desflurane.

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: To see if the use of intravenous clonidine, given at induction of general anaesthesia, decreases the consumption of desflurane (a routinely used volatile anaesthetic agent). ;Secondary Objective: Nil;Primary end point(s): Reduction in desflurane consumption.