Continuous Versus Repetitive Sevoflurane Administration for Preconditioning
- Registration Number
- NCT00569816
- Lead Sponsor
- University Hospital Schleswig-Holstein
- Brief Summary
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Patients schedulded to undergo CABG surgery
- Age 18 to 80 years
- Ejection fraction > 40%
Exclusion Criteria
- Emergency cases
- Diabetes
- Not able to give informed consent
- Ejection fraction < 40%
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Group 2 Sevoflurane Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass. Group 1 Sevoflurane Propofol as the primary anesthetic Group 3 Sevoflurane Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.
- Primary Outcome Measures
Name Time Method Myocardial cell damage as assessed by plasma levels of Troponin T from induction of anesthesia until hospital discharge
- Secondary Outcome Measures
Name Time Method Length of stay on the ICU and in the hospital from hospital admission until hospital discharge
Trial Locations
- Locations (1)
University Hospital Schleswig-Holstein, Campus Kiel
🇩🇪Kiel, Germany