Continuous Versus Repetitive Sevoflurane Administration for Preconditioning

Phase 4

Completed

• Conditions: Myocardial Injury
• Interventions: Drug: Sevoflurane

• Registration Number: NCT00569816
• Lead Sponsor: University Hospital Schleswig-Holstein

Brief Summary

Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.

Detailed Description

Not available

Study Timeline

• Study Start: 2005-01
• Study Completion: 2007-05
• Status Verified: 2007-11
• Study First Submitted: 2007-12-06
• Study First Submitted QC: 2007-12-06
• Last Update Submitted: 2007-12-06
• Study First Posted: 2007-12-07
• Last Update Posted: 2007-12-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

• Patients schedulded to undergo CABG surgery
• Age 18 to 80 years
• Ejection fraction > 40%

Exclusion Criteria

• Emergency cases
• Diabetes
• Not able to give informed consent
• Ejection fraction < 40%

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Group 2	Sevoflurane	Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass.
Group 1	Sevoflurane	Propofol as the primary anesthetic
Group 3	Sevoflurane	Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.

Primary Outcome Measures

Name	Time	Method
Myocardial cell damage as assessed by plasma levels of Troponin T	from induction of anesthesia until hospital discharge

Secondary Outcome Measures

Name	Time	Method
Length of stay on the ICU and in the hospital	from hospital admission until hospital discharge

Trial Locations

Locations (1)

University Hospital Schleswig-Holstein, Campus Kiel; 🇩🇪 Kiel, Germany