A Comparison Between Continuous and Repetitive Sevoflurane Administration for Preconditioning During Coronary Artery Bypass Surgery
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Myocardial cell damage as assessed by plasma levels of Troponin T
研究概览
简要总结
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients schedulded to undergo CABG surgery
- •Age 18 to 80 years
- •Ejection fraction > 40%
排除标准
- •Emergency cases
- •Not able to give informed consent
- •Ejection fraction < 40%
研究组 & 干预措施
Group 1
Propofol as the primary anesthetic
干预措施: Sevoflurane (Drug)
Group 2
Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass.
干预措施: Sevoflurane (Drug)
Group 3
Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.
干预措施: Sevoflurane (Drug)
结局指标
主要结局
Myocardial cell damage as assessed by plasma levels of Troponin T
时间窗: from induction of anesthesia until hospital discharge
次要结局
- Length of stay on the ICU and in the hospital(from hospital admission until hospital discharge)