A Comparison Between Continuous and Repetitive Sevoflurane Administration for Preconditioning During Coronary Artery Bypass Surgery
Overview
- Phase
- Phase 4
- Intervention
- Sevoflurane
- Conditions
- Myocardial Injury
- Sponsor
- University Hospital Schleswig-Holstein
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Myocardial cell damage as assessed by plasma levels of Troponin T
- Status
- Completed
- Last Updated
- 18 years ago
Overview
Brief Summary
Pharmacologic preconditioning by volatile anesthetics may depend on the mode of administration. The researchers hypothesize that a continuous administration in patients scheduled for CABG surgery prebypass will be less effective in terms of attenuating myocardial cell damage compared to a repetitive administration with a double wash in/wash out schedule. A control group will receive propofol as their primary anesthetic.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients schedulded to undergo CABG surgery
- •Age 18 to 80 years
- •Ejection fraction \> 40%
Exclusion Criteria
- •Emergency cases
- •Not able to give informed consent
- •Ejection fraction \< 40%
Arms & Interventions
Group 1
Propofol as the primary anesthetic
Intervention: Sevoflurane
Group 2
Sevoflurane administered continuously after induction of anesthesia until initiation of cardiopulmonary bypass.
Intervention: Sevoflurane
Group 3
Sevoflurane administered repetitive up to 1 MAC from induction of anesthesia until initiation of cardiopulmonary bypass. Wash in and wash out performed twice.
Intervention: Sevoflurane
Outcomes
Primary Outcomes
Myocardial cell damage as assessed by plasma levels of Troponin T
Time Frame: from induction of anesthesia until hospital discharge
Secondary Outcomes
- Length of stay on the ICU and in the hospital(from hospital admission until hospital discharge)