NL-OMON39900CompletedNot Applicable
Preoperative identification of response to neoadjuvant chemoradiotherapy for esophageal cancer - PRIOR
niversitair Medisch Centrum Utrecht0 sites30 target enrollmentStarted: TBDLast updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •- Histologically confirmed carcinoma of the esophagus or esophagogastric junction (i.e. tumors involving both cardia and esophagus on endoscopy)
- •- Potentially resectable tumor (cT1b-4a N0-3 M0)
- •- Undergoing neoadjuvant chemoradiation according to CROSS-regimen
- •- Age >18 years
- •- No history of other cancer or previous radiotherapy or chemotherapy
- •- Signed informed consent
Exclusion Criteria
- •- Patients who meet exclusion criteria for MRI at 1.5T following the protocol of the Radiology department of the UMC Utrecht
- •- Glomerular Filtration Rate (GFR) of <45 mL/min/1.73m2, unless the patient has risk factors for contrast nefropathy according to the UMC Utrecht protocol *Preventie contrastreactie en contrast nefropathie, Versie 2 februari 2012*. In patients with risk factors a minimum GFR of 60 mL/min/1.73m2 will be required
- •- Patients with insulin dependent diabetes mellitus or a blood plasma glucose concentration higher than 10 mmol/L
- •- Patients with a known Gadovist allergy
- •- Patients with a known CT-contrast allergy
- •- Patients having difficulty understanding Dutch
- •- Pregnant or breast-feeding patients
Investigators
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