Association Between Sugar Sweetened Beverage Intake and Biomarkers of Cardiometabolic Risk in US Women
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 33,000
- 试验地点
- 1
- 主要终点
- Fetuin-A
研究概览
简要总结
This study is a secondary analysis of data collected in the Nurses' Health Study (NHS) that will evaluat the association between intake of sugar sweetened beverages (SSB), juice and artificially sweetened beverages in relation to biomarkers of hepatic function, lipid metabolism, inflammation and glycemic control.
详细描述
The investigators will analyze cross-sectional data from 8,492 participants in the Nurses' Health Study who were free of diabetes and cardiovascular disease to evaluate the association between intake of sugar sweetened beverages (SSB), juice and artificially sweetened beverages (ASB) and biomarkers of hepatic function, lipid metabolism, inflammation and glycemic control. Biomarkers were measured from blood samples that were collected in 2 cycles, approximately 10 years apart.
Specifically, multivariate linear regression will be used to assess the associations of SSB, ASB, and fruit juice intake with concentrations of fetuin-A, alanine transaminase, gamma-glutamyl transferase, triglycerides, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, C-reactive protein (CRP), intracellular adhesion molecule 1 (ICAM-1), vascular cell adhesion protein 1 (VCAM-1), adiponectin, insulin, and hemoglobin A1c as well as total cholesterol/HDL-C ratio.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 55 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •For the current study, we included participants who provided a blood sample and were previously selected as controls for nested case-control analyses of type 2 diabetes, coronary heart disease, stroke, colon cancer, colon polyps, pancreatic cancer, and breast cancer in the Nurse's Health Study.
排除标准
- •Participants with self-reported prevalent diabetes or cardiovascular disease (CVD) at blood draw were excluded. After exclusions, a total of 8,492 individuals (6,961 from cycle 1 and 1,531 from cycle 2) with valid beverage intake data were included in the current analysis.
结局指标
主要结局
Fetuin-A
时间窗: Blood collection cyle 2 (2000-2001)
Biomarkers of liver function
Alanine transaminase
时间窗: Blood collection cyle 2 (2000-2001)
Biomarkers of liver function
Gamma-glutamyl transferase
时间窗: Blood collection cyle 2 (2000-2001)
Biomarkers of liver function
次要结局
- Total cholesterol(Blood collection cycle 2 (2000-2001))
- Triglycerides(Blood collection cycle 2 (2000-2001))
- Low-density lipoprotein cholesterol (LDL-C)(Blood collection cycle 2 (2000-2001))
- Total cholesterol/HDL-C ratio(Blood collection cycle 2 (2000-2001))
- Intracellular adhesion molecule 1 (ICAM-1)(Blood collection cycle 2 (2000-2001))
- Vascular cell adhesion protein 1 (VCAM-1)(Blood collection cycle 2 (2000-2001))
- High-density lipoprotein cholesterol (HDL-C)(Blood collection cycle 2 (2000-2001))
- C-reactive protein (CRP)(Blood collection cycle 2 (2000-2001))
- Insulin(Blood collection cycle 2 (2000-2001))
- Hemoglobin A1c(Blood collection cycle 2 (2000-2001))
研究者
Vasanti Malik
Research Scientist
Harvard School of Public Health (HSPH)