The efficacy of topical Hydroquinon with and without using Erbium YAG LASER in treatment of melasma
Phase 3
Recruiting
- Conditions
- Melasma.ChloasmaL81.1
- Registration Number
- IRCT20181201041812N1
- Lead Sponsor
- Tehran University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 27
Inclusion Criteria
Symmetrical melasma in both half of the face
Patients satisfaction
Skin type 1-3
Exclusion Criteria
Pregnancy or lactation
Use of alpha hydroxy acids and other drugs effect on pigmentation during past 4 weeks
Use of topical and oral retinoid
Use of topical steroid
Use of Oral Contraceptive Pills
Chemical peeling ,microderm abrasion, derm abrasion or LASER during past 3 months
History of keloid
History of past sensitivity to hydroquinon
History of thyroid dysfunction
LASER therapy in past 3 months
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pigmentation. Timepoint: Before intervention,at the end of intervention,1 mouth and 3 mouths after end of intervention. Method of measurement: Modified Melasma Area and Severity Index(mMASI) score,digital photography,patient satisfaction(questionnaire),physician assessment.;Topical adverse effects. Timepoint: Every month in intervention period and the end of intervention. Method of measurement: Questionnaire and observation.
- Secondary Outcome Measures
Name Time Method