NCT00966199UnknownPhase 4
Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly
Radboud University Medical Center1 site in 1 country60 target enrollmentStarted: September 2009Last updated:
Conditions
Interventions
Drugs
Trial Snapshot
- Phase
- Phase 4
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Cerebral blood flow
Study Overview
Brief Summary
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.
Study Design
- Study Type
- Interventional
- Allocation
- Non Randomized
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Eligibility Criteria
- Ages
- 70 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Age >= 70 years
- •Systolic office blood pressure >= 160 mmHg
- •Systolic home blood pressure >= 155 mmHg
Exclusion Criteria
- •Diabetes Mellitus
- •Atrial fibrillation
- •Renal failure requiring dialysis
- •Life expectancy of less than 1 year
- •Disabling stroke
- •Contraindication for MRI or anti-hypertensive medication
- •Systolic blood pressure > 220 mmHg
Arms & Interventions
Hypertensive elderly
Experimental
community dwelling hypertensive elderly from general practices
Intervention: anti-hypertensive medication (Drug)
Outcomes
Primary Outcomes
Cerebral blood flow
Time Frame: T1, 8-12 weeks of treatment, T2
Secondary Outcomes
- Cognitive functioning assessed by neuropsychological testing(T1, 8-12 weeks of treatment, T2-3)
Investigators
Study Sites (1)
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