NCT00966199
Unknown
Phase 4
Medication Induced Blood Pressure Reduction; Assessment of Cerebral Perfusion and Cognition in Hypertensive Elderly
Overview
- Phase
- Phase 4
- Intervention
- anti-hypertensive medication
- Conditions
- Hypertension
- Sponsor
- Radboud University Medical Center
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- Cerebral blood flow
- Last Updated
- 16 years ago
Overview
Brief Summary
The purpose of this study is to determine if a reduction in systolic blood pressure induced by anti-hypertensive medication results in changes in cerebral perfusion and cognition in hypertensive elderly. Hypertensive elderly will be treated using open-label anti-hypertensive medication for 8-12 weeks. Changes in cerebral perfusion and cognition will be assessed before and after treatment.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Age \>= 70 years
- •Systolic office blood pressure \>= 160 mmHg
- •Systolic home blood pressure \>= 155 mmHg
Exclusion Criteria
- •Diabetes Mellitus
- •Atrial fibrillation
- •Renal failure requiring dialysis
- •Life expectancy of less than 1 year
- •Disabling stroke
- •Contraindication for MRI or anti-hypertensive medication
- •Systolic blood pressure \> 220 mmHg
Arms & Interventions
Hypertensive elderly
community dwelling hypertensive elderly from general practices
Intervention: anti-hypertensive medication
Outcomes
Primary Outcomes
Cerebral blood flow
Time Frame: T1, 8-12 weeks of treatment, T2
Secondary Outcomes
- Cognitive functioning assessed by neuropsychological testing(T1, 8-12 weeks of treatment, T2-3)
Study Sites (1)
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