Transcranial Direct Current Stimulation in Post-stroke Fatigue

Not Applicable

Completed

• Conditions: Fatigue; Stroke

• Registration Number: NCT04634864
• Lead Sponsor: University College, London

Brief Summary

This is a double-blind, sham-controlled, anodal tDCS study to understand the effect of increasing motor cortex excitability on post-stroke fatigue.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-01-10
• Primary Completion: 2019-08-08
• Study Completion: 2019-08-08
• Status Verified: 2020-11
• Study First Submitted: 2020-11-12
• Study First Submitted QC: 2020-11-17
• Last Update Submitted: 2020-11-17
• Study First Posted: 2020-11-18
• Last Update Posted: 2020-11-18

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 33

Inclusion Criteria

Diagnosed with stroke at least 3 months post-stroke

Exclusion Criteria

Other neurological conditions on Anti-depressants severe motor impairment (affected hand grip <60% unaffected hand) severe cognitive impairment (unable to follow instructions, or give informed consent) scored >11 in the depression sub-section of HADS questionnaire contraindications for TMS or tES

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Fatigue Severity Scale - 7	2 weeks	a questionnaire based fatigue scale

Secondary Outcome Measures

Name	Time	Method
Input-output curves	1 day	This is a measure of cortical recruitment as measured by transcranial magnetic stimulation
Perceived effort - Explicit	1 day	A VAS scale associated with a grip task
Resting Motor Threshold	1 day	This is a measure of cortical excitability as measured by transcranial magnetic stimulation
Perceived effort - Implicit	1 day	A novel line length estimation task

Trial Locations

Locations (1)

33 Queen Square, Institute of Neurology, UCL; 🇬🇧 London, United Kingdom