A Randomized Controlled Trial Study of the Use of Transcranial Direct Current Stimulation (tDCS) in Treating Dysarthria Post-stroke
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 9
- 试验地点
- 1
- 主要终点
- Acoustic measurement: Intensity perturbation (shimmer %)
研究概览
简要总结
The proposed study aimed to determine if tDCS can help post-stroke patients with dysarthria.
详细描述
A total of 9 Cantonese-speaking chronic post-stroke patients who are suffering from dysarthria was recruited and randomly divided into treatment group and sham group. For the treatment group, an anodal high-definition tDCS of 2 milliampere (mA) lasting for 15 minutes was delivered to the primary motor cortex (SM1) in 10 daily sessions during a 2-week period. For the sham tDCS group, the same setting of tDCS electrodes was applied on the scalp, but the stimulation only lasted for 30 sec in order to cause similar sensation on the scalp as the other group. Simultaneous to the tDCS stimulation, both groups will receive speech and voice therapy for 30 minutes.
An array of outcome measures reflecting speech production ability including acoustic, kinematic, perceptual and self-perceptual qualities was obtained before and after stimulation. It was anticipated that post-stroke dysarthric patients will see improvement in speech production after stimulation. The results provided important insights into the effects of tDCS on articulatory movement in individuals with dysarthria post-stroke.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Cantonese-speaking adults
- •At least 6 months after their initial stroke
- •Dysarthria post-stroke
排除标准
- •A personal or family history of epilepsy or seizures
- •A history of another neurological condition
- •Speech disorders
- •Voice disorders
- •Oro-maxillo-facial surgery involving the tongue and/or lip
- •Severe cognitive impairment
- •Severe aphasia
- •Heart disease
- •Metallic foreign body implant
- •On medications that lower neural thresholds (e.g. tricyclines, antidepressants, neuroleptic agents, etc.)
结局指标
主要结局
Acoustic measurement: Intensity perturbation (shimmer %)
时间窗: Change before and after tDCS stimulation at immediately post-treatment
Intensity perturbation (shimmer %) was obtained from sustained vowel phonation.
Acoustic measurement: Harmonic to noise ratio (HNR)
时间窗: Change before and after tDCS stimulation at immediately post-treatment
Harmonic to noise ratio (HNR) was obtained from sustained vowel phonation.
Acoustic measurement: Frequency perturbation (jitter %)
时间窗: Change before and after tDCS stimulation at immediately post-treatment
Frequency perturbation (jitter %) was obtained from sustained vowel phonation.
Acoustic measurement: Noise to harmonic ratio (NHR)
时间窗: Change before and after tDCS stimulation at immediately post-treatment
Noise to harmonic ratio (NHR) was obtained from sustained vowel phonation.
Perceptual speech assessments
时间窗: Change before and after tDCS stimulation at immediately post-treatment
All participants were required to produce a sustained vowel /a/, repeated some syllables (i.e., /pa/, /ta/, /ka/ and /pataka/), produce some single words, read a standard paragraph in Cantonese and had a two-minute conversation with the investigator. A professional grade microphone (SM58, Shure, USA) was used to record the speech production. Experienced speech-language pathologists blinded to the neurological condition and history of each participant analyzed the speech samples independently using a perceptual rating scale including 21 speech dimensions covering eight categories, including pitch, loudness, voice quality, resonance, rate, articulation, tone, and general impression. The speech samples were rated using a seven-point equal-appearing interval scale, with a "1" indicating within typical limit performance and a "7" severely deviated from the normal.
Acoustic measurement: Fundamental frequency (F0)
时间窗: Change before and after tDCS stimulation at immediately post-treatment
Fundamental frequency (F0) was obtained from sustained vowel phonation.
次要结局
- Kinematic measurement: Duration(Change before and after tDCS stimulation at immediately post-treatment)
- Kinematic measurement: Maximum deceleration(Change before and after tDCS stimulation at immediately post-treatment)
- Kinematic measurement: Maximum velocity(Change before and after tDCS stimulation at immediately post-treatment)
- Kinematic measurement: Distance(Change before and after tDCS stimulation at immediately post-treatment)
- Kinematic measurement: Maximum acceleration(Change before and after tDCS stimulation at immediately post-treatment)
研究者
Dr. Lawrence M.W. Ng
Associate Professor
The University of Hong Kong