The Neural Correlates of Mood and Cognitive Bias in a Population at Risk for Depression: Maternal Cognitive and Emotional Functioning
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Stanford University
- Enrollment
- 240
- Locations
- 2
- Primary Endpoint
- Onset of depression
Study Overview
Brief Summary
The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.
Detailed Description
The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 9 Years to 15 Years (Child)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old.
- •Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.
Exclusion Criteria
- •Eligible mothers cannot:
- •currently be in treatment for drug or alcohol abuse
- •have significant symptomatology related to psychopathology outside of depression
- •have a medical history of neurological injury or impairment.
- •Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.
Outcomes
Primary Outcomes
Onset of depression
Time Frame: 18 months
participants are interviewed in an 18-month follow-up session
Secondary Outcomes
No secondary outcomes reported