Mothers With a History of Depression and Their 10-14 Year Old Daughters

Completed

• Conditions: Depressive Disorder, Major; Depression
• Interventions: Other: No intervention

• Registration Number: NCT01129752
• Lead Sponsor: Stanford University

Brief Summary

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. The investigators are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters.

Detailed Description

The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted cross-generationally. We are conducting an integrative assessment of emotion regulation and stress reactivity in a group of mothers with and without a history of depression and their daughters. We use a range of methodologies to evaluate these processes, including self-report measures, information-processing performance, HPA-axis functioning and reactivity, and neural responses to emotional stimuli following exposure to stressful experiences.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2004-02
• Study First Submitted: 2010-05-21
• Study First Submitted QC: 2010-05-24
• Study First Posted: 2010-05-25
• Primary Completion: 2011-04
• Study Completion: 2011-04
• Status Verified: 2011-06
• Last Update Submitted: 2011-06-21
• Last Update Posted: 2011-06-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 240

Inclusion Criteria

• Eligible mothers must read and speak English fluently and have a child between the ages of 9 and 15 years old.
• Mothers must either have no history of psychopathology or have a history of depression during their child's lifetime.

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Exclusion Criteria

• Eligible mothers cannot:

  • currently be in treatment for drug or alcohol abuse
  • have significant symptomatology related to psychopathology outside of depression
  • have a medical history of neurological injury or impairment.

• Mothers who meet the requirements for inclusion in the control group must not have a history of any Axis I disorder.

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
children at risk for depression	No intervention	children at familial risk for depression

Primary Outcome Measures

Name	Time	Method
Onset of depression	18 months	participants are interviewed in an 18-month follow-up session

Trial Locations

Locations (2)

Stanford University Department of Psychology; 🇺🇸 Stanford, California, United States

Stanford University School of Medicine; 🇺🇸 Stanford, California, United States