The role of intensive insulin therapy in critically ill medical and surgical patients
- Conditions
- Critically ill medical and surgical patientsNot ApplicableIntensive care unit
- Registration Number
- ISRCTN07413772
- Lead Sponsor
- King Fahad National Guard Hospital (Saudi Arabia)
- Brief Summary
2008 results in: http://www.ncbi.nlm.nih.gov/pubmed/18936702 2018 nested cohort study results in: http://www.ncbi.nlm.nih.gov/pubmed/29769112
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 522
1. Adults (greater than 18 years old) able to give consent (directly or via proxy)
2. Random admission blood glucose level greater than 6.1 mM/l (greater than 110 mg/dl)
1. Type I diabetes
2. Patients admitted with diabetic ketoacidosis
3. Patients with terminal illness (survival judged by the treating physician less than four weeks)
4. Patients with do not resuscitate (DNR) orders
5. Pregnancy
6. Patients with expected intensive care unit (ICU) length of stay (LOS) of less than 24 hours
7. History of hypoglycaemia during the same hospitalisation
8. Seizure disorder (known active in the last 6 months)
9. Post-cardiac arrest patients
10. Readmission to ICU within the same hospitalisation
11. Brain death
12. Liver transplant
13. Enrolled in another competing study
14. Refused consent
15. No consent within 24 hours of meeting inclusion criteria
16. Other reasons
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method All cause mortality in the IC
- Secondary Outcome Measures
Name Time Method 1. Hospital outcome<br>2. Cause of death<br>3. ICU and hospital LOS<br>4. Mechanical ventilation duration<br>5. The need for renal replacement therapy<br>6. Transfusion requirements<br>7. ICU acquired infections<br>8. Causes of death