The role of insulin therapy in reducing critical illness polyneuropathy and myopathy in pediatric intensive care unit

Phase 2

• Conditions: polyneuropathy and myopathy.; Diabetic polyneuropathy; E10,E11.E1

• Registration Number: IRCT201108117295N1
• Lead Sponsor: Vice chancellor for research, Tabriz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Inclusion criteria and who are under investigation in this study are the following:
In this study,during one year and a half,30 of patients admitted to the pediatric intensive care unit of Tabriz Children's Hospital and are more than one week under mechanical ventilation and in the course of their hospitalization experience hyperglycemia (more than 180 milligram per decilitre) are divided into two groups; In first group with 15 patient insulin is used in order to keep blood sugar in range of 140-180 milligram per decilitre (until the patient is connected to the ventilator); In second group with 15 patient,distilled water as placebo will be used (Note that injection will be done by a person who has no information about the polyneuropathy and myopathy).
Confounding variables are important in this study and the following people are excluded from study; spinal cord injuries; patients with Guillain Barre Syndrome; myasthenia gravis; patients with central nervous system problems or neuromuscular disease causing muscle weakness and paralysis
before or during the hospitalization; hypophosphatemia.
Appropriate methods to control confounding variables are according to observation,periods of physical examination,laboratory results such as blood and cerebro spinal fluid tests and EMG and NCV. It should be noted that the removal of these patients are so that in each point of the study (before the start of or during the study) if each of 5 problems above found by methods such as Electromygraphy and testing of cerebrospinal fluid or physical examination period,the patient will be excluded.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood glucose. Timepoint: Serial monitoring of blood glucose per hour (the aim of maintaining blood glucose range 140-180 milligram per decilitre). Method of measurement: Glucometry.

Secondary Outcome Measures

Name	Time	Method
Polyneuropathy and myopathy. Timepoint: After extubation. Method of measurement: Electromyography.