From Gene to Neural Function in ADHD. Enriching the Dutch Database of the International Multisite ADHD Genetics (IMAGE) Project.

Conditions: 10009841
ADHD
attention-deficit/hyperactivity disorder

Registration Number: NL-OMON32726

Lead Sponsor: niversitair Medisch Centrum Sint Radboud

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 1000

Inclusion Criteria

Previous inclusion criteria: ADHD-families: at least one proband with the combined subtype of ADHD and at least one sibling and one parent available for testing. Children between the ages of 5 and 18 were included.
Control-children: no ADHD and no ADHD in their first-degree relatives. Children between the ages of 5 and 18 were included.;For the current follow-up: all children are contacted and tested again, regardless of previous in- and exclusion criteria allowing for studying remitted cases of ADHD (or new ADHD cases in the control group).

Exclusion Criteria

(1) IQ<70, (2) a diagnosis of schizophrenia or autism that might confound the diagnosis of ADHD, and (3) neurological disorders such as epilepsy and brain injury, as well as any genetic or medical disorder associated with externalising behaviors that might mimic ADHD.

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Assessments will be scheduled 5 to 6 years after the baseline assessments. sMRI<br /><br>(30 min) and fMRI (60 min, while presenting the stop-task and a spatial working<br /><br>memory task) data will be acquired. Phenotyping will follow similar procedures<br /><br>as at baseline, and include a semi-structured investigator-based interview to<br /><br>categorically classify ADHD, and questionnaires to obtain dimensional scores of<br /><br>ADHD symptoms and related comorbidity. Outside the scanner, 8 other<br /><br>neuropsychological tasks will be administered to the children (set-shifting,<br /><br>verbal working memory, time reproduction, motor timing, motor control, motor<br /><br>speed, intelligence, and positive and negative reinforcement). Parents will be<br /><br>assessed using the same 10 neuropsychological tasks outside the scanner, and be<br /><br>phenotyped using questionnaires.</p><br>

Secondary Outcome Measures