Resistance Exercise to Improve Vaccine Outcomes in Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 29
- 试验地点
- 2
- 主要终点
- Cell mediated immunity change at 6 weeks post-vaccine
研究概览
简要总结
This study evaluates whether resistance exercise will improve immune responses to the seasonal influenza vaccine in older adults. One third of the participants will perform exercise in the arm that receives the vaccine, one third of the participants will perform the same exercise in the arm that does not receive the vaccine, and one third will only receive the vaccine.
详细描述
Resistance exercise, particularly novel eccentric exercise, recruits immune cells to the targeted muscle. The exercises selected here targets the deltoid and biceps brachii muscles-those same muscles that the flu vaccine is delivered to during typical vaccination.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •non-frail older adult (≥65 years old) of any sex and race/ethnicity
- •non-smokers (>10 yrs)
- •meets American College of Sports Medicine criteria for participation in exercise
- •US resident
排除标准
- •underlying medical problems that contraindicate supervised resistance exercise
- •past or present history of autoimmune disease, HIV, hepatitis, stroke, or cardiovascular disease
- •current debilitating arthritis of the shoulder
- •central or peripheral nervous disorders
- •bedridden in the past three months
- •history of vaccine-related allergies, or severe egg allergy;
- •physician-confirmed influenza infection in the prior year
- •regular user of corticosteroids
- •functional or cognitive impairment that would limit exercise performance or prohibit informed consent
- •blood pressure greater than 160/90
- •participation in resistance arm exercises in the prior 6 months
结局指标
主要结局
Cell mediated immunity change at 6 weeks post-vaccine
时间窗: baseline and 6 weeks
The change in the peripheral blood mononuclear cell response to overnight ex vivo culture with the seasonal quadrivalent vaccine detected via Interferon-gamma ELISPOT will be calculated from baseline at 6 weeks post-vaccine
Antibody titer change at 6 weeks post-vaccine
时间窗: baseline and 6 weeks
The change in influenza-specific antibody titers in serum measured by hemagglutination inhibition assay will be calculated from baseline at 6 weeks post-vaccine
Antibody titer change at 6 months post-vaccine
时间窗: baseline and 6 months
The change in influenza-specific antibody titers in serum measured by hemagglutination inhibition assay will be calculated from baseline at 6 months post-vaccine
Cell mediated immunity change at 6 months post-vaccine
时间窗: baseline and 6 months
The change in the peripheral blood mononuclear cell response to overnight ex vivo culture with the seasonal quadrivalent vaccine detected via Interferon-gamma ELISPOT will be calculated from baseline at 6 months post-vaccine
次要结局
- Influenza-like symptoms(Measured monthly for six months)
- Muscle soreness(7 days)
研究者
Emily C Lavoy
Assistant Professor
University of Houston