Immune Response and Risk of Side Effects After Influenza Vaccination in Athletes
Overview
- Phase
- Phase 4
- Intervention
- Not specified
- Conditions
- Influenza Virus Vaccine Adverse Reaction
- Sponsor
- Universität des Saarlandes
- Enrollment
- 45
- Primary Endpoint
- Immune response
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
Seasonal influenza vaccination was used to assess whether induction of immunity as well as the rate of side effects is influenced by the timing of the last training session before vaccination. Healthy athletes were vaccinated with the tetravalent influenza vaccine and blood samples were collected before, 1, 2 and 26 weeks after vaccination. The athletes were randomly assigned to vaccination within 2 hours after the last training session ("2h") vs. vaccination after a resting period of at least 26 hours ("26h"). All participants documented side effects and training restrictions. Influenza-specific T-cells were quantified after stimulation with the vaccine based on intracellular cytokine staining. Antibodies were quantified by ELISA and neutralisation assay.
Investigators
Eligibility Criteria
Inclusion Criteria
- •performance-oriented training on at least five days a week, healthy athletes
Exclusion Criteria
- •current acute infection, allergy to the vaccine, immunosuppression, pregnancy, rheumatic diseases
Outcomes
Primary Outcomes
Immune response
Time Frame: 26 weeks
Influenza-specific T-cells were quantified after stimulation with the vaccine based on intracellular cytokine staining. Antibodies were quantified by ELISA and neutralisation assay.
Rate of side effects
Time Frame: 2 weeks
All participants documented side effects and training restrictions.