Can memantine prevent memory impairment induced by MDMA in humans

Completed

• Conditions: cognitief functioneren; geheugenproblemen en medierend mechanisme

• Registration Number: NL-OMON37941
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 21

Inclusion Criteria

Recreational MDMA users (used at least 3 times of which at least once during the previous year, and maximally 200 times)
Age between 18 and 40 years
Free from psychotropic medication
Good physical health as determined by medical examination and laboratory analysis
Absence of any major medical, endocrine and neurological condition
Normal weight, body mass index (weight/height2) between 18.5 and 28 kg/m2
Written Informed Consent

Exclusion Criteria

History of drug abuse (other than the use of MDMA) or addiction
Pregnancy or lactation
Excessive drinking (> 20 alcoholic consumptions a week)
Hypertension (diastolic> 90; systolic> 140)
Current or history of psychiatric disorder
Liver dysfunctioning
(Serious) side effects to previous MDMA use
History of cardiac dysfunctions (arrhythmia, ischemic heart disease,*)
For women: no use of a reliable contraceptive

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Performance on memory tasks</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Event related potentials and speech recordings</p><br>