Neurobiology of Opioid Dependence: 5 - 5
Phase 2
Withdrawn
- Conditions
- Opioid-Related Disorders
- Registration Number
- NCT00000196
- Lead Sponsor
- Yale University
- Brief Summary
The purpose of this study is to determine the effect of acute naltrexone pretreatment on the response to yohimbine in healthy volunteers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
Not provided
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Behavioral, physiological, neuroendocrine response to yohimbine
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie naltrexone's effect on yohimbine response in opioid dependence?
How does naltrexone pretreatment compare to standard opioid withdrawal management strategies?
Are there specific biomarkers that predict individual response to naltrexone-yohimbine interaction in opioid disorders?
What adverse events are associated with acute naltrexone administration in healthy volunteers and how are they managed?
What are the potential therapeutic applications of naltrexone-yohimbine combination beyond opioid dependence research?
Trial Locations
- Locations (1)
VA Connecticut Healthcare System
🇺🇸New Haven, Connecticut, United States
VA Connecticut Healthcare System🇺🇸New Haven, Connecticut, United States