Regulation of Intracerebral Pressure During Electroconvulsive Therapy
- Conditions
- DepressionIntracranial Pressure
- Registration Number
- NCT00597831
- Lead Sponsor
- Rijnstate Hospital
- Brief Summary
The purpose of this study is to determine whether electroconvulsive therapy (ECT) has an influence on pressure within the human brain before, during and after ECT.
- Detailed Description
1. Aim:
1. Our main objective concerning this study is to determine to what extent ECT does lead to an increase of the Pulsatility Index (as an indicator of intracerebral pressure) measured by a Transcranial Doppler Device (TCD).
2. As a secondary objective we want to compare the PI measurements with simultaneously measured systemic blood pressure.
2. Study design:
a.Observational study: cohort study
3. Treatment:
a. Treatment as usual, PI and blood pressure measurement at baseline, just before ECT, during and 5 minutes after ECT. Data will be collected during unilateral treatment during 3 consecutive ECT treatments.
4. Endpoints:
1. A minimum of sixteen patients are needed according to the power analysis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
- Temporal window to measure PI
- Major depression
- Psychotic depression
- Under 18 years of age
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pulsatility Index before, during and after electroconvulsive therapy before, during and after three consecutive ECT treatments
- Secondary Outcome Measures
Name Time Method Bloodpressure before, during and after ECT. before, during and after three consecutive ECT treatments.
Trial Locations
- Locations (1)
PAAZ Rijnstate Hospital
🇳🇱Arnhem, Gelderland, Netherlands