Preventive multimodal analgesic effect of combined acetaminophen and ibuprofen for acute and chronic pain after breast cancer surgery: A randomized controlled trial

Not Applicable

Completed

• Conditions: Neoplasms

• Registration Number: KCT0007928
• Lead Sponsor: Chung-Ang University Gwangmyeong Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2023-09-19
• Last Update Posted: 16 October 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 92

Inclusion Criteria

A 20-80-year-old female patient with physical condition classification 1-2 of the American Society of Anesthesiologists undergoing breast conserving surgery

Exclusion Criteria

abnormality of liver function (AST or ALT 60 IU/L or more)
renal function deterioration (GFR 60ml/hr or less)
allergic to acetaminophen or nonsteroidal anti-inflammatory drugs
history of gastrointestinal ulcers or gastrointestinal bleeding
coagulation lab abnormalities (collagen/epinephrine > 257, PT INR > 1.15, aPTT > 45)
heart failure patients
history of bronchial asthma
pregnant
Those who taking barbituric drugs, tricyclic antidepressants, and high-dose methotrexate
use of intravenous patient controlled analgesic device
lumpectomy without lymph node dissection
Diseases that may indicate neuralgia of the upper extremities and upper body (cervical spine disease, herpes zoster, thoracic outlet syndrome, etc.)
Those who refused to participate in this study

Study & Design

• Study Type: Interventional Study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Morphine equivalent dose

Secondary Outcome Measures

Name	Time	Method
pain scoring, postoperative nausea/vomiting, and use of antiemetics