A Study comparing two different doses of Injection Dexmedetomidine when added to Injection Levobupivacaine (0.5% concentration) for ultrasound guided supraclavicular brachial plexus nerve block in elective upper limb surgeries.

Phase 4

Not yet recruiting

• Conditions: Medical and Surgical,

• Registration Number: CTRI/2023/02/050078
• Lead Sponsor: MGM Medical College and Hospital Aurangabad

Brief Summary

Brachial plexus block has evolved into an excellent substitute to general anaesthesia for upper limb surgeries. It curtails the stress response and using minimal anaesthetic drugs  it provides  intraoperative analgesia with prolonged post operative pain relief. Among the various upper limb blockades, supraclavicular brachial plexus block (SCBP) is considered as ’spinal of arm’.

Brachial plexus block is a peripheral block commonly used for upper limb surgery. Ultrasound guided supraclavicular brachial plexus block facilitate more accurate and effective method of drug administration.

Levobupivacaine is used for this study as it has advantages of long acting and less cardiotoxic and neurotoxic. Levobupivacaine has  recently been used more for supraclavicular brachial plexus block due to the above mentioned advantages.

The idea behind using an adjuvant with local anaesthetic is to reduce the requirement of analgesics in post operative period.

Various adjuvants have been studied for prolonging the effect of supraclavicular blocks(4). Alpha 2 adrenoreceptor agonist such as clonidine and dexmedetomidine are the two most commonly used drugs. They have shown sedation, analgesia, sympatholysis,cardiac stabilization and anaesthetic sparing properties. Out of these dexmedetomidine an imidazole compoind is more selective than clonidine(eight times).Dexmedetomidine causes analgesia by its action at supraspinal (locus coeruleus) or at spinal level or even at peripheral Alpha 2 receptors by the reduction of transmission of nociceptive stimulus.(2).

This study compares the effects of two different doses of dexmedetomidine as an adjuvant added to 0.5% Levobupivacaine. In our study we are using ultrasound guided technique for supraclavicular brachial plexus block.

In this study we hypothesise that two different doses of dexmedetomidine (0.5 & 1 microgram per kg) are equallyt effective.

Detailed Description

Not available

Study Timeline

• Last Update Posted: 2023-02-23
• Study Start: 2023-02-28

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 36

Inclusion Criteria

1.Patients of ASA physical grade I –II 2.18-65 years of age 3.Both sexes 4.Posted for elective surgeries of midarm forearm and hand will be included.

Exclusion Criteria

1.Patient refusal 2.History of infection at site of block 3.Coagulopathies 4.Patients with known hypersensitivity to local anaesthetic or dexmedetomidine 5.Presence of 1st, 2nd or 3rd degree heart block 6.Pregnant women 7.Patients on beta blockers Pre-existing peripheral neuropathy.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1)Heart rate	1.Time at which procedure of giving block is finished. | 2)Five minute | 3)Ten minute | 3)Fifteen minute | 4)Twenty minute | 5)Fourty minute
3)Saturation	1.Time at which procedure of giving block is finished. | 2)Five minute | 3)Ten minute | 3)Fifteen minute | 4)Twenty minute | 5)Fourty minute
2)Mean arterial pressure	1.Time at which procedure of giving block is finished. | 2)Five minute | 3)Ten minute | 3)Fifteen minute | 4)Twenty minute | 5)Fourty minute

Secondary Outcome Measures

Name	Time	Method
1.Heart rate	2.Mean arterial pressure

Trial Locations

Locations (1)

MGM MEDICAL COLLEGE AND HOSPITAL; 🇮🇳 Aurangabad, MAHARASHTRA, India

MGM MEDICAL COLLEGE AND HOSPITAL

🇮🇳Aurangabad, MAHARASHTRA, India

Dr Noel Tobin

Principal investigator

9496982892

noeltobinm@gmail.com