Randomized Clinical Trial of Intensive Computer-based Cognitive Remediation in Recent-onset Schizophrenia -Targeted Affective Remediation Approach (TARA)

Posit Science Corporation2 sites in 1 country16 target enrollmentMay 2012

ConditionsSchizophrenia

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Schizophrenia
Sponsor: Posit Science Corporation
Enrollment: 16
Locations: 2
Primary Endpoint: Social Functioning Scale
Status: Completed
Last Updated: 9 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

The purpose of this study is to test a new computerized training program as well as to find out whether the computer training might help people who have schizophrenia. The investigators will study the effects of the computer training on how people with schizophrenia think about social interaction and on their social skills. At completion of training, TARA subjects will show improvement on measures of social cognition compared to their baseline performance.

Detailed Description

This study employs two computerized programs: TARA (the treatment program), and a set of ordinary computer games (the active control program). Participants will be asked to use their assigned program (treatment or active control) for one hour per session, for four-five sessions per week, over 8-10 weeks (40 total sessions). Several elements of flexibility are allowed in the schedule to accommodate the challenges that people with ASD can face.

Registry

clinicaltrials.gov

Start Date

May 2012

End Date

July 2013

Last Updated

9 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Posit Science Corporation

Responsible Party

Sponsor

Eligibility Criteria

Inclusion Criteria

•The investigators will study outpatient volunteer subjects who have schizophrenia, schizophreniform disorder or schizoaffective disorder and have experienced their first psychotic episode within the past 5 years, who are clinically stable, and who are between the ages of 18 and 35 years. Approximately 35-40% of the subjects recruited will be female, approximately 50-60% of potential subjects will be Euro-American, 10-20% will be Asian-American, 15-20% Latino, 15-20% African-American. The subject sample will reflect the racial and ethnic diversity of Northern California and the prevalence of schizophrenia across gender in this age period.
•The investigators will study volunteer subjects at high risk for psychosis who are clinically stable, and who are between the ages of 12-
•Approximately 35-40% of the subjects recruited will be female, approximately 50-60% of potential subjects will be Euro-American, 10-20% will be Asian-American, 15-20% Latino, 15-20% African-American. Our subject sample will reflect the racial and ethnic diversity of the San Francisco Bay Area.
•The study will have volunteer healthy controls matched by age and gender to our subjects at high risk for psychosis.
•The study subjects will not have their medications changed by the study researchers. If a subject's personal doctor changes a medication, the change will simply be documented by the study researchers.
•Investigators will recruit subjects with a clinical diagnosis of schizophrenia, schizophreniform or schizoaffective disorder with first psychotic episode within the last 5 years, good general physical health; age between 12 and 35 years; Is fluent and proficient in the English language; no neurological disorder. In addition, all subjects must have achieved clinical stability, defined as outpatient status for at least 3 months prior to study participation, plus stable doses of psychiatric medications for at least one month prior to study participation using the following operationalized definition: stable low to moderate dose of antipsychotic medication (\<1000 mg. chlorpromazine equivalents) for at least 4 weeks prior to study, plus stable doses of all other psychotropic medications (anticholinergics, benzodiazepines) for at least 4 weeks prior to entry. However, subjects are not required to be on medications during participation. Minors must have parental/legal guardian consent to participate. Although investigators request that a family member also participate in the clinical assessments, this is not required for a participant to be eligible.
•This study will also recruit subjects who meet criteria for a Prodromal Syndrome as defined on the SIPS:
•Attenuated Positive Prodromal Syndrome: Ideas of reference, odd beliefs or magical thinking, paranoid ideation, odd thinking and speech, odd behavior and appearance that are at a prodromal level of intensity that is rated at the level of 3-5 on the Scale of Prodromal Symptoms (SOPS). Symptoms must occur at an average frequency of at least once per week in the past month.
•Brief Intermittent Psychotic Syndrome: Positive symptoms rated at psychotic intensity as a score of 6 on the SOPS that are not disorganizing or dangerous, do not last more than 1 hour per day at an average frequency of four days per week over one month, and have begun in the past three months, currently present at least several minutes a day at a frequency of at least once per month.
•Genetic Risk and Deterioration Syndrome: Schizotypal personality disorder OR first degree relative with a DSM-IV psychotic disorder, PLUS significant decrease in functioning defined as 30% or greater drop in GAF score during the last month compared to 12 months ago.

Exclusion Criteria

•Recent Onset Schizophrenia Subjects: Investigators will exclude subjects with a history of psychoactive substance abuse in past 6 months determined by DSM-IV criteria from the SCID interview.
•Prodromal Subjects: Psychotic disorder previously diagnosed as schizophrenia or schizoaffective disorder or psychotic syndrome as defined by the SIPS: Fully psychotic symptoms have occurred at least one hour per day at a minimum average frequency of 4 days per week over one month OR the psychotic symptom is seriously disorganizing or dangerous.
•Healthy Control Subjects: Criteria is met for any Axis I diagnosis on the SCID. Healthy controls cannot have any first or second degree relative with a diagnosis of schizophrenia, schizoaffective disorder, or bipolar disorder. Any previous psychiatric hospitalizations will exclude a healthy control from the study.
•Any subject presenting a significant danger to self or others who requires inpatient treatment will be referred for that treatment and evaluated for study eligibility only after acute care treatment is no longer necessary.
•Subjects will also be excluded if they have a neurological disorder, or mental retardation (IQ \< 70 previously documented, or by intellectual testing, if necessary), or autism.
•Physical disability that prohibits testing (deafness or blindness).
•Subjects will be excluded if they currently meet DSM-IV criteria for alcohol/substance dependence or has met criteria within the last 6 months OR prodromal symptoms are present only during use and withdrawal from alcohol/substances OR subject is unable to attend assessments sober.
•Any contraindications to receiving an MRI scan, including having metal implants or metal fragments in their body.
•Any history of head injury with loss of consciousness greater than 30 minutes.