The metabolic pathway of glutamine citrulline and arginine in surgical patients.
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 15
研究概览
简要总结
This present study is an amendment on a previous study that led to the following publications:
1. Boelens PG, Melis GC, van Leeuwen PA, Ten Have GA, Deutz NE. The route of administration (enteral or parenteral) affects the contribution of L-glutamine to the de novo L-arginine synthesis in mice. A stable isotope study. Am J Physiol Endocrinol Metab 6 A.D. Oct;291(4):E683-90;
2. Melis GC, Boelens PG, Van dS, Jr., Popovici T, De Bandt JP, Cynober L, et al. The feeding route (enteral or parenteral) affects the plasma response of the dipeptide Ala-Gln and the amino acids glutamine, citrulline and arginine, with the administration of Ala-Gln in preoperative patients. Br J Nutr 2005 Jul;94(1):19-26;
3. Boelens PG, van Leeuwen PA, Dejong CH, Deutz NE. Intestinal renal metabolism of L-citrulline and L-arginine following enteral or parenteral infusion of L-alanyl-L-[2,15N]glutamine or L-[2,15N]glutamine in mice. Am J Physiol Gastrointest Liver Physiol 2005 Oct;289(4):G679-G685;
4. Van de Poll MCG, Ligthart-Melis GC, Boelens PG, Deutz NEP, van Leeuwen PAM, Dejong CHC. Intestinal and hepatic metabolism of glutamine and citrulline in humans. J Physiol. 2007 June 1;581(Pt 2):819-27;
5. Van de Poll MCG, Siroen MPC, van Leeuwen PAM, Soeters SB, Melis GC, Boelens PG, Deutz NEP, Dejong CHC. Interorgan amino acid exchange in man: Concequences for arginine and citrulline metabolism. Am J Clin Nutr 2007; 85:167-72;
6. Ligthart-Melis GC, van de Poll MC, Dejong CH, Boelens PG, Deutz NE, van Leeuwen PA. The route of administration (enteral or parenteral) affects the conversion of isotopically labeled L-[2-15N]glutamine into citrulline and arginine in humans. JPEN J Parenter Enteral Nutr 2007 Sep;31(5):343-8;
7. Ligthart-Melis GC, van de Poll MC, Boelens PG, Dejong CH, Deutz NE, van Leeuwen PA. Glutamine is an important precursor for de novo synthesis of arginine in humans. Am J Clin Nutr 2008 May;87(5):1282-9;
8. Ligthart-Melis GC, van de Poll MC, Vermeulen MAR, van den Tol MP, Dejong CH, Boelens PG, De Bandt JP, van Leeuwen PA. Enteral administration of alanyl-[2-15N]glutamine contributes more to the synthesis of arginine than intravenous infusion of the dipeptide in humans. Am J Clin Nutr. 2009 Jul;90(1):95-105.
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •1. Patients undergoing aortic replacement surgery for abdominal aneurysm;
- •2. Age: > 35 and < 70 years;
排除标准
- •1. Patients not fit for surgery as decided by the anesthesiology department (renal/hepatic insufficiency or heart failure);
- •2. Hepatitis, severe cirrhosis, urea cycle disorders/citrullinemia;