An Investigation into the role of Matrix Metalloproteinases (MMPs) in Lower Limb Vascular Restenosis
Completed
- Conditions
- Surgery: CardiovascularSurgeryCardiovascular
- Registration Number
- ISRCTN35955220
- Lead Sponsor
- Record Provided by the NHSTCT Register - 2006 Update - Department of Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 270
Inclusion Criteria
Serum samples collected at the time of vascular intervention (radiologist or surgeon). Follow up samples by vascular research fellow.
Arterial wall and vein biopsies taken at the time of surgery by operating surgeon.
Exclusion Criteria
1. Patient unable to give informed consent
2. Age < 18 years
3. Pregnancy, planned pregnancy
4. Life expectancy less than 12 months
5. Inability to monitor the angioplasty site or graft with ultrasound for stenosis
6. Unable to take SDD (ie allergic reaction) or currently taking tetracyclines
7. Unable to take adjuvant treatment with antiplatelet/anticoagulant agent and statin
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method