Detection of infection with SELDI-tof in case of endophthalmitis.
Recruiting
- Conditions
- SELDI-tof,endophthalmitis, vitreous, macular pucker, macular hole.
- Registration Number
- NL-OMON28646
- Lead Sponsor
- Drs. P.A.W.J.F. Schellekens. ophthalmologist
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- Not specified
- Target Recruitment
- 110
Inclusion Criteria
Patients with endophthalmitis:
1. Able to give informed consent;
Exclusion Criteria
Endophthalmitis group:
1. Patients unable to give informed consent;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Three analyses will be performed with SELDI-tof in comparison to regular culture methods:<br /><br>1. Comparison of protein composition of vitreous in comparison to serum obtained bij surgery for maucular hole or <br>macular pucker: controll population;<br /><br>2. Comparison of protein composition of vitreous in comparison to serum of patients with endophthalmtis;<br /><br>3. Comparison of protein composition of vitreous in comparison to serum of patients with endophthalmitis versus <br>the controll population.
- Secondary Outcome Measures
Name Time Method 1. Evaluation of the correlation between specific bacterial causes of endophthalmitis indentified by culture and <br>specific protein pattern obtained via SELDI-tof analyses;<br /><br>2. Evaluation of the correlation of vitreous of endophthalmitis with a negative result with culture and the protein <br>pattern obtained by SELDI-tof analyses.<br /> We will compare the protein patterns of culture negative results with <br>peak pattern of bacteriae identified by culture.