Inherited Susceptible Genes Among Epithelial Ovarian Cancer
- Conditions
- Ovarian Neoplasm EpithelialHereditary Breast and Ovarian Cancer Syndrome
- Registration Number
- NCT03015376
- Lead Sponsor
- Peking Union Medical College Hospital
- Brief Summary
Purpose: To investigate the prevalence of the germline mutations in the BRCA 1/2 and mismatch repair genes in patients with epithelial ovarian cancer (EOC) and their relatives, and related somatic mutations in tumor tissues in the northern part of china.
Patients and methods: A multicenter prospective study will be hold in the northern part of china form 2017. About 1000 female patients with epithelial ovarian cancer and their ralatives will be tested for germline mutations in the BRCA 1/2 and mismatch repair genes and related somatic mutations in tumor tissues, regardless of the family history.
Study type: Observational Official title: Prevalence study of germline mutations in susceptibility ovarian cancer genes in patients with epithelial ovarian cancer and somatic mutations in their tumor tissures in the northern part of china.
Enrollment: 1000
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 1000
- epithelial ovarian cancer and their relatves
- living in the north of Huaihe River in China
- being Han Chinese
- non-epithelial ovarian cancer
- without specific pathological diagnosis
- non-Han Chinese
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method herited gene mutations susceptible to epithelial ovarian cancer in patients and their relatives two years
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Lei Li
🇨🇳Beijing, Beijing, China
Peking Union Medical College Hospital
🇨🇳Beijing, Beijing, China