Proteomics of Severe Traumatic Brain Injury: A Feasibility Study

• Conditions: Brain Injuries, Traumatic

• Registration Number: NCT00522496
• Lead Sponsor: University of Calgary

Brief Summary

The purpose of this study is to:

1. Determine the temporal course of matrix metalloproteinase (MMP) expression in patients wiht severe traumatic brain injury

2. Determine the temporal course of the expression of MMP-related inflammatory mediators of secondary injury in patients with severe traumatic brain injury

3. Describe the association of physiological changes and standard microdialysis analyte measures (lactate, pyruvate, lactate/pyruvate ratio, and glucose) to MMP and neuroinflammatory marker concentrations.

Detailed Description

Not available

Study Timeline

• Study Start: 2007-07
• Study First Submitted: 2007-08-27
• Study First Submitted QC: 2007-08-27
• Study First Posted: 2007-08-29
• Status Verified: 2009-02
• Last Update Submitted: 2009-02-20
• Last Update Posted: 2009-02-24
• Study Completion: 2009-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 8

Inclusion Criteria

• Patient is 18 years of age or older
• Patient has GCS less than 9
• Patient requires intracranial pressure monitoring
• Patient life expectancy greater than 72 hours

Exclusion Criteria

• Patient's TBI is greater than 24 hours old
• Patient is less than 18 years of age
• Patient does not require intracranial pressure monitoring
• Patient has life expectancy less than 72 hours
• Patient has GCS greater or equal to 9
• Patient is currently enrolled in another study

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Foothills Medical Centre; 🇨🇦 Calgary, Alberta, Canada