NL-OMON44516
Recruiting
Not Applicable
Molecular studies on reduced ovarian reserve and embryo competence in BRCA1/2 mutation carriers - BRCA1/2, ovarian reserve and embryo competence (ORCA)
Medisch Universitair Ziekenhuis Maastricht0 sites104 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- hereditary breast cancer
- Sponsor
- Medisch Universitair Ziekenhuis Maastricht
- Enrollment
- 104
- Status
- Recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\-IVF/PGD treatment for a BRCA1/2\-mutation, both male and female mutation carriers (Control group A and Test group, respectively)
- •\-IVF/PGD treatment because the male partner has an autosomal dominant hereditary disorder (such as but not restricted to Huntingtons disease or Marfan syndrome) or both male/female partners carry a autosomal recessive hereditary disorder (such as but not restricted to cystic fibrosis or spinal muscular atrophy )(Control group B)
Exclusion Criteria
- •\- Known hereditary disease other than due to BRCA1/2\-mutations in the female
- •\- Known genetic abnormalities in female leading to diminished ovarian reserve: carriers of fragile X syndrome or abnormalities of the X\-chromosome
- •\- Hereditary disease in male known to affect embryo development
- •\- Known history of a malignancy in the female
- •\- Endocrine or metabolic abnormalities (pituitary, adrenal, pancreas, liver or renal)
- •\- History of cancer treatment in the female or male
- •\- Non\-Dutch couples, not able to understand the patient information to give informed consent properly
Outcomes
Primary Outcomes
Not specified
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