Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages?

Recruiting

• Conditions: Miscarriage, Recurrent; Miscarriage; Infertility, Female; IVF
• Interventions: Diagnostic Test: Transvaginal ultrasound; Diagnostic Test: Blood test AMH

• Registration Number: NCT05969574
• Lead Sponsor: ART Fertility Clinics LLC

Brief Summary

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

Detailed Description

By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function.

Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

Study Timeline

• Study First Submitted: 2023-07-24
• Study First Submitted QC: 2023-07-24
• Study First Posted: 2023-08-01
• Study Start: 2023-09-09
• Status Verified: 2025-01
• Last Update Submitted: 2025-02-17
• Last Update Posted: 2025-02-19
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: Female
• Target Recruitment: 2059

Inclusion Criteria

1. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai)

Exclusion Criteria

1. Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT))
2. Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation
3. Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound
4. History of ovarian surgery, chemotherapy, or radiation therapy
5. Known genetic disorder or chromosomal abnormality
6. BMI >40Kg/m2
7. Currently using hormonal contraception or hormone replacement therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
AMH <1.3, at least 1 pregnancy and no miscarriage	Transvaginal ultrasound	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH <1.3, at least 1 pregnancy and no miscarriage	Blood test AMH	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH ≥ 1.3, at least 1 pregnancy or at least 1 miscarriage	Transvaginal ultrasound	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.ons.
AMH <1.3, at least 1 pregnancy or at least 1 miscarriage	Transvaginal ultrasound	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH <1.3, at least 1 pregnancy or at least 1 miscarriage	Blood test AMH	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH ≥1.3, at least 1 pregnancy and no miscarriage	Transvaginal ultrasound	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH ≥1.3, at least 1 pregnancy and no miscarriage	Blood test AMH	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.
AMH ≥ 1.3, at least 1 pregnancy or at least 1 miscarriage	Blood test AMH	Participants will not undergo any additional intervention compared to normal clinical assessment and routine testing of the ovarian reserve, which includes AMH and AFC. Investigators will follow standard stimulation protocols and medications.ons.

Primary Outcome Measures

Name	Time	Method
AMH	1 day	Anti-Müllerian Hormone Test
AFC	1 day	Antral follicle count

Trial Locations

Locations (3)

ART Fertility Clinics LLC; 🇦🇪 Abu Dhabi, United Arab Emirates

ART Fertility Clinics Al Ain; 🇦🇪 Al Ain, United Arab Emirates

ART Fertility Clinics Dubai; 🇦🇪 Dubai, United Arab Emirates