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临床试验/NCT05969574
NCT05969574招募中不适用

Is Decreased Ovarian Reserve Related to an Increased Number of Previous Early Miscarriages? A Prospective Observational Study

ART Fertility Clinics LLC5 个研究点 分布在 1 个国家目标入组 2,059 人开始时间: 2023年9月9日最近更新:
适应症

试验速览

阶段
不适用
状态
招募中
入组人数
2,059
试验地点
5
主要终点
AMH

研究概览

简要总结

This study aims to explore the potential correlation between decreased ovarian reserve and previous history of early miscarriage.

详细描述

By investigating the prevalence of low ovarian reserve (LOR) in populations with specific reproductive histories (such as recurrent pregnancy loss, G0, and ectopic pregnancy), as well as the aneuploidy rates of embryos produced with Preimplantation Genetic Testing for Aneuploidies (PGT-A), Investigators can better understand how LOR impacts fertility outcomes in these populations. This information can be used to inform clinical decision-making, such as whether participants with LOR should consider alternative or whether they would benefit from additional interventions to improve ovarian function.

Ultimately, by improving our understanding of how LOR impacts fertility outcomes in specific populations, Investigators can help to improve the overall success rates of infertility treatment, reduce anxiety, and distress, and help participants achieve goals of becoming parents.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

性别
Female
接受健康志愿者

入选标准

  • 1. All participants with at least 1 previous pregnancy, who are assessed in one of our clinics (ART Fertility Clinics Abu Dhabi, Al Ain, Dubai)

排除标准

  • Severe male factor (azoospermia, cryptozoospermia, severe oligoasthenoteratozoospermia (OAT))
  • Severe Endometriosis and adenomyosis based on positive anamnesis or ultrasound performed in our center during the first consultation
  • Uterine abnormalities (e.g. fibroids, different degrees of uterine septum), diagnosed by ultrasound
  • History of ovarian surgery, chemotherapy, or radiation therapy
  • Known genetic disorder or chromosomal abnormality
  • BMI >40Kg/m2
  • Currently using hormonal contraception or hormone replacement therapy

结局指标

主要结局

AMH

时间窗: 1 day

Anti-Müllerian Hormone Test

AFC

时间窗: 1 day

Antral follicle count

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Laura Melado

IVF Specialist

ART Fertility Clinics LLC

研究点 (5)

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