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Efficacy and Safety of Diclofenac Sodium Gel (DSG) in Knee Osteoarthritis

Phase 3
Completed
Conditions
Osteoarthritis of the Knee
Interventions
Registration Number
NCT00426621
Lead Sponsor
Novartis
Brief Summary

This study will test the efficacy and safety of topical diclofenac sodium gel in the treatment of knee osteoarthritis.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
420
Inclusion Criteria
  • Osteoarthritis of the knee
Exclusion Criteria
  • Other rheumatic disease, such as rheumatoid arthritis
  • Active gastrointestinal ulcer during the last year
  • Known allergy to analgesic drugs
  • Other protocol defined inclusion/exclusion criteria may apply.

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
1Diclofenac Sodium Gel-
2Placebo-
Primary Outcome Measures
NameTimeMethod
pain in the target knee (WOMAC pain index);
functional capacity in the target knee (WOMAC function index); and
global rating of benefit (100 mm Visual Analogue Scale, VAS).
Secondary Outcome Measures
NameTimeMethod
Efficacy of Diclofenac Sodium Gel 1% with regard attainment of:
Low pain intensity in either knee; and
Low functional impairment in either knee.
Safety of Diclofenac Sodium Gel 1% assessed by:
monitoring adverse events; and
laboratory evaluations.

Trial Locations

Locations (61)

Holston Medical Group

🇺🇸

Kingsport, Tennessee, United States

North Carolina Arthritis & Allergy Care Center

🇺🇸

Raleigh, North Carolina, United States

Texas Research Center, LLP

🇺🇸

Sugar Land, Texas, United States

Universal BioPharma Research, Inc.

🇺🇸

Fresno, California, United States

MED Investigations

🇺🇸

Carmichael, California, United States

Coastal Clinical Research Inc

🇺🇸

Mobile, Alabama, United States

Radiant Research - Anderson

🇺🇸

Anderson, South Carolina, United States

Heartland Research Associates, LLC

🇺🇸

Wichita, Kansas, United States

AppleMed Research, Inc.

🇺🇸

Miami, Florida, United States

Rapid Medical Research, Inc

🇺🇸

Cleveland, Ohio, United States

HOPE Research Institute

🇺🇸

Phoenix, Arizona, United States

Quality Research, Inc.

🇺🇸

San Antonio, Texas, United States

Radiant Research - San Antonio

🇺🇸

San Antonio, Texas, United States

Twin Cities Clinical Research

🇺🇸

Brooklyn Center, Minnesota, United States

River Region Research, LLC

🇺🇸

Tallassee, Alabama, United States

MED Investigations, Inc.

🇺🇸

Fair Oaks, California, United States

Santa Barbara Clinical Research, Inc

🇺🇸

Santa Barbara, California, United States

Pacific Arthritis Center Medical Group

🇺🇸

Santa Maria, California, United States

Radiant Research

🇺🇸

Philadelphia, Pennsylvania, United States

Medical Specialists Clinical Research Center

🇺🇸

Munster, Indiana, United States

St. Louis Center for Clinical Research

🇺🇸

St. Louis, Missouri, United States

The Center for Pharmaceutical Research

🇺🇸

Kansas City, Missouri, United States

Clinical Research Source, Inc

🇺🇸

Perrysburg, Ohio, United States

Omega Medical Research

🇺🇸

Warwick, Rhode Island, United States

Radiant Research Dallas North

🇺🇸

Dallas, Texas, United States

Amarillo Center for Clinical Research

🇺🇸

Amarillo, Texas, United States

Walter F. Chase, M.D., P.A.

🇺🇸

Austin, Texas, United States

Tidewater Integrated Medical Research

🇺🇸

Virginia Beach, Virginia, United States

Health Research of Hampton Roads, Inc.

🇺🇸

Newport News, Virginia, United States

The Physicians Clinic of Spokane

🇺🇸

Spokane, Washington, United States

South Jersey Medical Associates, PA

🇺🇸

Blackwood, New Jersey, United States

Andres Patron DO PA

🇺🇸

Pembroke Pines, Florida, United States

East Valley Family Physicians

🇺🇸

Chandler, Arizona, United States

South Florida Clinical Research Center

🇺🇸

Hollywood, Florida, United States

Florida Medical Research Institute

🇺🇸

Gainesville, Florida, United States

Health Awareness, Inc.

🇺🇸

Jupiter, Florida, United States

Lovelace Scientific Research, Inc.

🇺🇸

Beverly Hills, California, United States

Sunrise Medical Research

🇺🇸

Plantation, Florida, United States

Peninsula Research, Inc.

🇺🇸

Ormond Beach, Florida, United States

Radiant Research - St Petersburg

🇺🇸

Pinellas Park, Florida, United States

Peter A. Holt, MD

🇺🇸

Baltimore, Maryland, United States

Internal Medical Associates

🇺🇸

Grand Island, Nebraska, United States

Radiant Research, Inc. - Akron

🇺🇸

Mogadore, Ohio, United States

Neshaminy Medical, PC

🇺🇸

Bensalem, Pennsylvania, United States

Westminster Family Medicine

🇺🇸

Erie, Pennsylvania, United States

Feasterville Family Health Care Center

🇺🇸

Feasterville, Pennsylvania, United States

Southeastern Pennsylvania Medical Institute

🇺🇸

Havertown, Pennsylvania, United States

Advanced Healthcare

🇺🇸

Milwaukee, Wisconsin, United States

Suncoast Internal Medicine Consultants

🇺🇸

Largo, Florida, United States

Clinical Research Consultants, LLC

🇺🇸

Stratford, Connecticut, United States

Professional Clinical Research, Inc

🇺🇸

Cadillac, Michigan, United States

Heartland Research Associates LLC

🇺🇸

Arkansas City, Arkansas, United States

Seidman Clinical Trials

🇺🇸

Delray Beach, Florida, United States

Phase III Clinical Research

🇺🇸

Fall River, Massachusetts, United States

Sunshine Research Center, LLC

🇺🇸

Opa Locka, Florida, United States

Coastal Medical Research

🇺🇸

Port Orange, Florida, United States

Best Clinical Trial, LLC

🇺🇸

New Orleans, Louisiana, United States

University Clinical Research, Inc.

🇺🇸

Pembroke Pines, Florida, United States

Intermountain Orthopaedics

🇺🇸

Boise, Idaho, United States

Suncoast Clinical Research, Inc.

🇺🇸

New Port Richey, Florida, United States

The Center for Rheumatology and Bone Research

🇺🇸

Wheaton, Maryland, United States

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