Hematological Indices in Pre-eclampsia

Not yet recruiting

Conditions: Mild to moderate pre-eclampsia,

Registration Number: CTRI/2020/07/026623

Lead Sponsor: All India Institute Of Medical Sciences Raipur

Brief Summary: Preeclampsiais associated with increased maternal and fetal morbidity. Activation ofinflammatory responses leads to widespread endothelial dysfunction andresultant manifestations of multi organ dysfunction in Preeclampsia. Earlyrecognition of Preeclampsia and its severity will help in guiding optimalobstetric management in pregnant women. Hematological indices such as Neutrophil to Lymphocyte ratio, Platelet tolymphocyte ratio, Mean Platelet volume, Platelet distribution width,Plateletcrit, Red cell Distribution Width and Delta Neutrophil Index,givesan insight to the underlying inflammation in Preeclampsia.

These indices can be used as an emerging toolin prediction of pre-eclampsia as well as a marker is estimating the severityof pre-eclampsia. Its predictive value could be used for early diagnosis,timely referral and intervention to avoid life-threatening complication ofpre-eclampsia.

Moreover,these indices are easy, inexpensive to measure, reproducible and can be used asa marker of underlying inflammation in preeclampsia.

Therehas been small number of researches on the use of these indices to predictpre-eclampsia as well as severity of pre-eclampsia. Therefore, the presentstudy aims to study the role of hematological indices such as Neutrophil to Lymphocyte ratio, Plateletto lymphocyte ratio, Mean Platelet volume, Platelet distribution width,Plateletcrit, Red cell Distribution Width and Delta Neutrophil Index, as predictors of pre-eclampsia.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: Female

Target Recruitment: 270

Inclusion Criteria

Pregnant women of age 18-40years, with singleton pregnancy and 13-20 weeks gestational age, attending antenatal care: Outpatient department (OPD) and/or Inpatient department (IPD) in department of Obstetrics and Gynecology at All India Institute of Medical Sciences, Raipur and giving fully valid consent to participate in the study.

Exclusion Criteria

â—Age < 18 years and > 40 years â—Multi fetal pregnancy â—Women who have co existing medical illness oChronic Hypertension oDiabetes mellitus oChronic liver disease oChronic Kidney disease oEstablished Cardiovascular disease oCollagen vascular disease oHematological disease oOngoing infection or systemic inflammatory conditions oAutoimmune disease â—History of Smoking, alcoholism and drug abuse â—Pregnancy complications like membrane rupture or intrauterine fetal death â—History of fever, HELLP.
â—Patient refusal to participate in study.

Study & Design

Study Type: Observational

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To study the role of the Hematological indices such as Neutrophil to Lymphocyte ratio, Platelet to lymphocyte ratio, Mean Platelet Volume, Platelet distribution width, Red cell Distribution Width and Delta Neutrophil Index as predictors of pre-eclampsia.	from the time of recruitment till 6 weeks postpartum

Secondary Outcome Measures

Name	Time	Method
a) To study the role of Hematological indices such as Neutrophil to Lymphocyte ratio, Platelet to lymphocyte ratio, Mean Platelet Volume, Platelet distribution width, Red cell Distribution Width and Delta Neutrophil Index as markers of severity in women with pre-eclampsia.	b) To determine the diagnostic accuracy of Neutrophil to Lymphocyte ratio, Platelet to lymphocyte ratio for the diagnosis of severe and non-severe pre-eclampsia.

Trial Locations

Locations (1): AIIMS RAIPUR
🇮🇳
Raipur, CHHATTISGARH, India
AIIMS RAIPUR
🇮🇳Raipur, CHHATTISGARH, India
Dr Kodumuri Loukya
Principal investigator
9963018886
kodumuriloukya@gmail.com