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Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria

Recruiting
Conditions
Colorectal Cancer (CRC)
Colorectal Cancer and Pre-cancer Polyps
Blood Stream Infection
Anaerobic Infection
Bacteriaemia
Registration Number
NCT06919068
Lead Sponsor
Odense University Hospital
Brief Summary

The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. The main question it aims to answer is:

• How prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? Participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
100
Inclusion Criteria
  • Older than 18 years
  • Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus.
  • Able to provide oral and written informed consent
  • Able to read and speak Danish
Exclusion Criteria
  • Prior colorectal cancer diagnosis
  • History of stenosis of the gastrointestinal tract
  • Previous treatment of inflammatory bowel disease
  • Previous major surgery of the gastrointesinal tract (e.g. gastric bypass)
  • Colostomy
  • Pacemaker/ICD
  • Pregnancy or breastfeeding
  • Allergies to the bowel preparation regimen
  • Severe kidney disease
  • Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer)
  • Tumor in the colon or rectum at diagnostic imaging
  • Discharge before result of blood culture
  • Transfer to other hospital outside the region

Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Primary Outcome Measures
NameTimeMethod
Colorectal cancer and precancerous tumors4-8 weeks after hospitalization with anaerobic gut-associated bacteria

Prevalence of colorectal cancer and precancerous tumors using colon capsule endoscopy

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Odense University Hospital

🇩🇰

Odense, Denmark

Odense University Hospital
🇩🇰Odense, Denmark
Mark Bremholm Ellebæk, Professor
Contact
004540880511
Mark.Ellebaek1@rsyd.dk
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