Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria

Not yet recruiting

• Conditions: Colorectal Cancer (CRC); Colorectal Cancer and Pre-cancer Polyps; Blood Stream Infection; Anaerobic Infection; Bacteriaemia

• Registration Number: NCT06919068
• Lead Sponsor: Odense University Hospital

Brief Summary

The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria. The main question it aims to answer is:

• How prevalent is cancer and precancerous tumors in the large intestines and rectum in patients with anaerobic bacteremia? Participants will be offered an examination using colon capsule endoscopy 4-8 weeks after discharge.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-04
• Study Start: 2025-04
• Study First Submitted: 2025-04-02
• Study First Submitted QC: 2025-04-02
• Last Update Submitted: 2025-04-02
• Study First Posted: 2025-04-09
• Last Update Posted: 2025-04-09
• Primary Completion: 2027-05
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Older than 18 years
• Blood culture with growth of one or more of the following bacterial genera Bacteroides, Clostridium, Filifactor, Fusobacterium, Gemella, Granulicatella, Parvimonas, Peptostreptococcus, Prevotella, Solobacterium, Peptoniphilus, Ruminococcus, Finegoldia and Streptococcus.
• Able to provide oral and written informed consent

Exclusion Criteria

• History of stenosis of the gastrointestinal tract
• Previous treatment of inflammatory bowel disease
• Previous major surgery of the gastrointesinal tract (e.g. gastric bypass)
• Colostomy
• Pacemaker/ICD
• Pregnancy or breastfeeding
• Allergies to the bowel preparation regimen
• Severe kidney disease
• Focus of infection in skin and soft tissue or outside the truncus (e.g. decubitus, diabetic foot ulcer)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Colorectal cancer and precancerous tumors	4-8 weeks after hospitalization with anaerobic gut-associated bacteria	Prevalence of colorectal cancer and precancerous tumors using colon capsule endoscopy

Trial Locations

Locations (1)

Odense University Hospital; 🇩🇰 Odense, Denmark