Efficacy of Intense Pulsed Light in the Treatment of Recurrent Chalazia

Not Applicable

• Conditions: Chalazion
• Interventions: Device: IPL-MGX

• Registration Number: NCT05070611
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

The purpose of the present study was to investigate the efficacy of intense pulse light and meibomian glands expression in cases of recurrent chalazion after surgery.

Detailed Description

We hypothesized that IPL application on the skin adjacent to eyelids after chalazion surgery will result in better meibomian gland function and lower recurrence. To date, it has not been previously reported the outcomes of the use of this technology for the management of chalazions recurrence. The purpose of the present study was to investigate the efficacy of intense pulse light and meibomian glands expression in cases of recurrent chalazion after surgery.

Study Timeline

• Study Start: 2020-07-01
• Primary Completion: 2020-08-01
• Status Verified: 2021-09
• Study First Submitted: 2021-09-09
• Study First Submitted QC: 2021-09-27
• Last Update Submitted: 2021-09-27
• Study First Posted: 2021-10-07
• Last Update Posted: 2021-10-07
• Study Completion: 2021-11-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 35

Inclusion Criteria

• All patients had chronic unilateral recurrent chalazia that failed to resolve after conservative treatment that included warm compresses and antibiotic and steroid ophthalmic ointments.

Exclusion Criteria

• (1) any intraocular inflammation, ocular infection, allergy, ocular surgery, or ocular trauma in the past 6 months; (2) any eyelid diseases or structural abnormality; (3) any systematic diseases may lead to dry eye or MGD; (4) skin cancer or pigmented lesion in the treatment zone.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Recurrent chalazia with IPL-MGX	IPL-MGX	The patients whose lesions had failed to respond to warm compresses and antibiotic and steroid treatment underwent incision and curettage. One week after lesion incision, the E-Eye machine (E-SWIN company, France) IPL treatment was administered to the skin area below the lower eyelid. After removal of the ultrasound gel, meibomian gland expression (MGX) was performed with forceps-shaped meibomian gland compressor.

Primary Outcome Measures

Name	Time	Method
Recurrence rate of chalazia	an average of 1 year	The recurrence rate of the recurrent chalazia

Secondary Outcome Measures

Name	Time	Method
meibomian expressibility and quality	an average of 1 year	The expressibility and quality score of the meibum
NITBUT	an average of 1 year	non-invasive tear film breakup time
TMH	an average of 1 year	tear meniscus height

Trial Locations

Locations (1)

Second Affiliated Hospital of Zhejiang University Hospital; 🇨🇳 Hangzhou, China