Firefighter Collaborative Research Project

Not Applicable

Active, not recruiting

• Conditions: Exposure; Cardiopulmonary
• Interventions: Behavioral: Surveys; Behavioral: Blood Donation; Behavioral: Zone 2 Training; Behavioral: Plasma Donation; Behavioral: Intermittent Fasting

• Registration Number: NCT05869747
• Lead Sponsor: University of Arizona

Brief Summary

The goal of this research is to test interventions to reduce firefighter cardiovascular, cognitive, and overall disease risks, including but not limited to risks associated with Per- and Polyfluorinated Substances (PFAS) exposure. Approximately 1,500 - 2,000 firefighters will be enrolled in the Fire Fighter Cancer Cohort Study (FFCCS). Among these individuals, those that express interest will then be screened for eligibility for the Firefighter Collaborative Research Project (FCRP) using information they provided for the Fire Fighter Cancer Cohort Study. Firefighters enrolled in the study will provide an initial blood sample and urine sample. The blood sample will be analyzed to determine the participant's PFAS levels. Based upon serum PFAS levels and responses from the screening survey, eligible participants will be randomly assigned into one of the following interventions: 1. Blood Donation, or Plasma Donation or Blood/Plasma Control Group; 2. Zone 2 Training or Zone 2 Control; 3. Intermittent Fasting or Intermittent Fasting Control. Individuals participating in the blood donation, plasma donation or blood/plasma control group would donate blood every 12 weeks, plasma every 6 weeks, or not donate blood or plasma. Participants in this intervention arm would continue this for a 12-month period. Individuals in the zone 2 training, zone 2 training control, intermittent fasting or intermittent fasting control group would participate in their intervention or control for a 4-month period. After 4 to 12 months participating in an intervention or control group, participants will be asked to provide a final urine sample and blood draw to determine if and to what degree their PFAS levels or other cardiovascular disease and other health risks have changed.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-04-24
• Study First Submitted QC: 2023-05-17
• Study First Posted: 2023-05-22
• Study Start: 2023-06-22
• Status Verified: 2025-01
• Last Update Submitted: 2025-05-29
• Last Update Posted: 2025-06-04
• Primary Completion: 2025-12-31
• Study Completion: 2025-12-31

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 1500

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Intermittent Fasting Control	Surveys	-
Plasma Donation	Surveys	-
Blood Donation	Surveys	-
Zone 2 Control	Surveys	-
Blood Donation	Blood Donation	-
Zone 2 Training	Zone 2 Training	-
Zone 2 Training	Surveys	-
Intermittent Fasting	Surveys	-
Plasma Donation	Plasma Donation	-
Blood/Plasma Control	Surveys	-
Intermittent Fasting	Intermittent Fasting	-

Primary Outcome Measures

Name	Time	Method
Change in concentration of PFAS levels in serum	12 months	PFAS levels are per- and polyfluoroalkyl substance levels measured from a biological sample
Change in epigenetic age	4 months	Epigenetic age is a mathematically derived age estimators that are based on combinations of methylation values that change with age at specific CpGs in the genome.

Trial Locations

Locations (7)

Gilbert Fire & Rescue Department; 🇺🇸 Gilbert, Arizona, United States

Green Valley Fire; 🇺🇸 Green Valley, Arizona, United States

Tucson Fire Department Headquarters; 🇺🇸 Tucson, Arizona, United States

Tucson Fire Department Station 9; 🇺🇸 Tucson, Arizona, United States

University of Arizona; 🇺🇸 Tucson, Arizona, United States

Northwest Fire District; 🇺🇸 Tucson, Arizona, United States

Drexel Heights Fire; 🇺🇸 Tucson, Arizona, United States