Efficacy of Ascorbic Acid for Prevention of Colistin-Associated Nephrotoxicity
- Registration Number
- NCT01501968
- Lead Sponsor
- Mahidol University
- Brief Summary
Ascorbic acid (Vitamin C) could protect renal toxicity from colistin.
- Detailed Description
Renal toxicity due to colistin therapy is common. Ascorbic acid (vitamin C) has been shown to prevent colistin associated renal toxicity in animals. This study is conducted to determine if acorbic acid can prevent Colistin-Associated Nephrotoxicity.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 54
Inclusion Criteria
- age > 18 years hospitalized patient who needs colistin for therapy of nosocomial infection
Exclusion Criteria
- pregnant woman
- lactating mother
- allergy to ascorbic acid
- receiving non-steroidal antiinflammatory drugs (NSAID), aminoglycosides, vancomycin, cisplatin, amphotericin-B
- received radiocontrast media within 1 week
- renal stone
- G-6-PD deficiency
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Colistin + Ascorbic acid Colistin + Ascorbic acid Colistimethate sodium 2.5-5mg/kg iv and ascorbic acid 2 grams iv every 12 hours Colistin Colistin Colistimethate sodium 2.5-5mg/kg iv
- Primary Outcome Measures
Name Time Method number of patients with Renal toxicity associated with colistin up to 28 days Renal toxicity associated with colistin according to RIFLE criteria
- Secondary Outcome Measures
Name Time Method number of subjects with cure or improvement up to 28 days cure improvement worse death
Trial Locations
- Locations (1)
Siriraj Hospital
đŸ‡¹đŸ‡Bangkok, Thailand