Menopausal Hormone Therapy And Left Ventricular Function

Not yet recruiting

• Conditions: Menopause; Left Ventricular Dysfunction
• Interventions: Drug: Menopausal Hormone Therapy

• Registration Number: NCT07242391
• Lead Sponsor: Mayo Clinic

Brief Summary

The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.

Detailed Description

Not available

Study Timeline

• Status Verified: 2025-11
• Study First Submitted: 2025-11-17
• Study First Submitted QC: 2025-11-17
• Last Update Submitted: 2025-11-17
• Study First Posted: 2025-11-21
• Last Update Posted: 2025-11-21
• Study Start: 2025-12-01
• Primary Completion: 2027-12
• Study Completion: 2027-12-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: Female
• Target Recruitment: 50

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Post-menopausal females using menopausal hormone therapy	Menopausal Hormone Therapy	Post menopausal females taking a clinically prescribed menopausal hormone therapy (i.e. pill, patch, etc.)

Primary Outcome Measures

Name	Time	Method
Left ventricular stroke volume	Baseline	Left ventricular stroke volume is the amount of blood pumped from the left ventricle per heartbeat (mL)

Secondary Outcome Measures

Name	Time	Method
Ventriculo-Arterial (VA) coupling	Baseline	Ventriculo-Arterial (VA) coupling will be measured as the ratio of end-systolic elastance (Ees) to arterial elastance (Ea).

Trial Locations

Locations (1)

Mayo Clinic in Rochester; 🇺🇸 Rochester, Minnesota, United States