Inspiratory Muscle Training and Asthma
Not Applicable
Completed
- Conditions
- Asthma
- Interventions
- Other: inspiratory muscle training
- Registration Number
- NCT01727765
- Lead Sponsor
- University of Portsmouth
- Brief Summary
This is a pilot study which will assess the feasibility of a follow on main study. This study will examine the impact of inspiratory muscle training on quality of life, rescue drug medication usage, and other markers of asthma in adult asthmatics in the UK.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 16
Inclusion Criteria
- Asthma Control Questionnaire score of ≥ 1.5
- 10 mg or less of prednisolone (or equivalent) daily
- Aged 18 to 59 years inclusive
- Able to provide written informed consent
Exclusion Criteria
- Any significant heart or lung disease other than asthma including any previous history of pneumothorax
- Patients with a concomitant condition (including clinically relevant cardiovascular, hepatic, neurological, endocrine, or other major systemic disease) not controlled with treatment, making implementation of the protocol or interpretation of the study results difficult
- Women who are pregnant
- Forced expiratory volume in one second of less than 50% best or predicted
- A history of smoking 20 cigarettes a day for 20 years or more (or an equivalent amount)
- Undertaken a structured program of inspiratory muscle training within the past three months
- Currently a participant in another interventional study
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Experimental inspiratory muscle training 6 weeks of inspiratory muscle training, 6 days per week. The intensity of training will be equivalent to up to 50% of pre-training maximal inspiratory mouth pressure and will be adapted weekly to reflect the improvement in inspiratory muscle strength Sham Comparator inspiratory muscle training 6 weeks of sham inspiratory muscle training, 6 days per week. The intensity of training will be equivalent to 5% of pre-training inspiratory mouth pressure throughout the 6 week period.
- Primary Outcome Measures
Name Time Method Maximal Inspiratory Mouth Pressure (MIP) pre (after the 4 week run-in) and post 6 weeks of IMT MIP is a surrogate measure of inspiratory muscle strength and was measured pre and post 6 weeks of either experimental or sham inspiratory muscle trianing (IMT).
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (2)
Respiratory Centre, Queen Alexandra Hospital, Cosham
🇬🇧Portsmouth, Hampshire, United Kingdom
University of Portsmouth
🇬🇧Portsmouth, Hampshire, United Kingdom