Role of mitochondrial gene polymorphisms in Gestational Diabetes Mellitus patients
Not Applicable
- Conditions
- Health Condition 1: O244- Gestational diabetes mellitus
- Registration Number
- CTRI/2021/06/034137
- Lead Sponsor
- Department of Biochemistry Maulana Azad Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
For Cases:
Primigravida Diagnosed GDM patients based on DIPSI Criteria (Diabetes in Pregnancy Study Group India).
For Controls:
Non-GDM Primigravida pregnant subjects with normal glucose tolerance.
Exclusion Criteria
1. Subjects with Hypothyroidism.
2. Subjects with Chronic inflammatory diseases.
3. Subjects with Type 1 or Type 2 Diabetes Mellitus.
4. Subjects with known mitochondrial dysfunction(s).
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To establish an association between mtDNA mutations, GDM and leptin.Timepoint: Baseline: To establish an association between tRNALeu(UUR) gene and ND1 gene polymorphism, GDM and leptin.
- Secondary Outcome Measures
Name Time Method To understand role of mitochondria in pathophysiology of GDM.Timepoint: At baseline only: A positive association may link the role of mitochondrial gene polymorphisms and leptin in the pathophysiology of GDM.