Atrial and Ventricular Wall Stress During Breathing
Not Applicable
Completed
- Conditions
- Healthy
- Interventions
- Other: Simple breathing manuevers during brief echocardiographic imaging
- Registration Number
- NCT03436030
- Lead Sponsor
- Umeå University
- Brief Summary
Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.
- Detailed Description
With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
- healthy adults
Exclusion Criteria
- known heart or lung disease
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Single arm, breathing manuevers Simple breathing manuevers during brief echocardiographic imaging All subjects perform/undergo Valsalva, Muller, CPAP, hand grip, and passive leg raise, with ultrasound examination of heart recorded before and during the manoeuvre.
- Primary Outcome Measures
Name Time Method Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver 30 seconds, i.e. control measurement and then measurement during breathing manoeuver observed from same breathing/measurement sequence Echocardiographic measure, comparing control measurement to measurement during breathing manoeuver
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Umeå University, and the University Hospital of Umeå
🇸🇪Umeå, Sweden