Atrial and Ventricular Wall Stress During Breathing

Not Applicable

Completed

• Conditions: Healthy

• Registration Number: NCT03436030
• Lead Sponsor: Umeå University

Brief Summary

Healthy reclining adult volunteers, with Valsalva manoeuver, Muller manoeuver, light continuous positive airway pressure by mask, passive leg raising, and maximal hand-grip. Ultrasound heart images captured before and during.

Detailed Description

With focus on atrial wall strain and strain-rate, In healthy volunteer adult subjects, heart ultrasound is recorded during resting, Valsalva manoeuver, Muller manoeuver, passive leg raising, and handgrip. Echocardiographic recordings are made before and during each intervention. Participants are otherwise resting in a reclined position.

Study Timeline

• Study Start: 2017-11-18
• Study First Submitted: 2017-12-15
• Status Verified: 2018-02
• Study First Submitted QC: 2018-02-15
• Study First Posted: 2018-02-19
• Primary Completion: 2018-04-30
• Study Completion: 2018-04-30
• Last Update Submitted: 2019-04-19
• Last Update Posted: 2019-04-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• healthy adults

Exclusion Criteria

• known heart or lung disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Change in atrial wall stress during breathing manoeuver, compared to control measurement immediately before the breathing manoeuver	30 seconds, i.e. control measurement and then measurement during breathing manoeuver observed from same breathing/measurement sequence	Echocardiographic measure, comparing control measurement to measurement during breathing manoeuver

Trial Locations

Locations (1)

Umeå University, and the University Hospital of Umeå; 🇸🇪 Umeå, Sweden