Short Atrioventricular Delay Pacing

Not Applicable

Withdrawn

• Conditions: Stable Cardiac Status (i.e. no Hospitalizations or Cardiac Medication Changes Within 3 Months); Chronically (i.e. Implanted for at Least Six Months) Dual-chamber Pacemaker
• Interventions: Other: short AVD pacing ; prior (stable) programming

• Registration Number: NCT01233661
• Lead Sponsor: University of Pittsburgh

Brief Summary

We intend to examine the effects of temporary elevation of atrial wall stress by shortening of the atrioventricular delay in patients with dual-chamber pacemakers.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2010-11-02
• Study First Submitted QC: 2010-11-02
• Study First Posted: 2010-11-03
• Study Start: 2011-01
• Primary Completion: 2011-01
• Study Completion: 2011-01
• Status Verified: 2016-01
• Last Update Submitted: 2023-03-21
• Last Update Posted: 2023-03-22

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Chronically (i.e. implanted for at least six months) dual-chamber pacemaker
• Stable cardiac status (i.e. no hospitalizations or cardiac medication changes within 3 months)
• Ability to provide informed consent

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Exclusion Criteria

• Age <18 years or >80 years
• Pregnancy (if pregnancy is suspected, a urine pregnancy test will be performed)
• Recent (within 12 months) left ventricular ejection fraction <50%
• Significant valvular heart disease (mitral regurgitation of greater than mild severity, any degree of mitral stenosis, aortic stenosis or insufficiency of greater than mild severity)
• Prior coronary artery bypass graft or valve surgery, recent (i.e. within 3 months) acute coronary syndrome or percutaneous coronary intervention, or chronic stable angina
• History of clinically important atrial or ventricular tachyarrhythmias, defined as complex ventricular ectopy (i.e. couplets, triplets, or ventricular tachycardia), AF, atrial tachycardia, or other supraventricular tachycardias not cured with prior ablative therapy).
• Significant chronic systemic inflammatory or neoplastic disease
• Chronic renal or hepatic insufficiency. Renal insufficiency will be defined as a creatinine clearance of less than 20 cc/min. Evidence of hepatic insufficiency will consist of abnormal synthetic function (INR >1.4 without oral anticoagulant use, albumin < 3.0 mg/dL) or abnormal clearance function (total bilirubin >2.0).
• Uncorrected thyroid abnormalities

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
short AVD pacing	short AVD pacing ; prior (stable) programming	short AVD pacing

Primary Outcome Measures

Name	Time	Method
serum biomarker concentrations	30 days

Trial Locations

Locations (1)

Atrial Arrhythmia Center, UPMC; 🇺🇸 Pittsburgh, Pennsylvania, United States