Impact of Pacing Site and AV Delay on Blood Pressure in Hypertensive Patients: An Acute Study in Patients Undergoing an Electrophysiology Study or Pacemaker Implant
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Change of blood pressure upon initiation of pacing with AV delays of 20 ms
研究概览
简要总结
The purpose of this study is to test whether the A-V sequential pacing strategy shown to effectively reduce blood pressure in a dog model of hypertension also reduces blood pressure acutely in patients with hypertension (systolic blood pressure greater than 140 mmHg) despite medical treatments.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient has hypertension with systolic blood pressure >140 mmHg despite at least one antihypertensive medication.
- •Patient has a clinical indication for a pacemaker or an electrophysiology study involving introduction of transvenous electrophysiology catheters to the right atrium and/or right ventricle.
- •Patient is willing and able to provide informed consent
排除标准
- •Patient is in atrial fibrillation at the time of the study
- •Patient has an ejection fraction less than 45%
- •Patient has a history of symptomatic heart failure, regardless of EF
- •Patient is undergoing an ablation procedure for a bypass track (WPW)
- •Patient has a history of resuscitation from ventricular fibrillation or sustained ventricular tachycardia
结局指标
主要结局
Change of blood pressure upon initiation of pacing with AV delays of 20 ms
时间窗: Approx. 5 minutes after initiating pacing with the respective AV delay
Change of blood pressure upon initiation of pacing with AV delays of 80 ms
时间窗: Approx. 5 minutes after initiating pacing with the respective AV delay
Assessment of any adverse effects
时间窗: Over a 24 hour period following the acute tests
Change of blood pressure upon initiation of pacing with AV delays of 40 ms
时间窗: Approx. 5 minutes after initiating pacing with the respective AV delay
Change of blood pressure upon initiation of pacing with AV delays of 2 ms
时间窗: Approx. 5 minutes after initiating pacing with the respective AV delay
次要结局
未报告次要终点