Dexmedetomidine Versus Fentanyl Added to Levobupivacaine for Transversus Abdominis Plane (TAP) Block in Elderly Patients Undergoing Lower Abdominal Surgery
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- first analgesic request
研究概览
简要总结
The perioperative management of pain following lower abdominal surgery can pose a challenge to anesthesia providers. Conventional practice has involved the use of opioids as well as neuraxial analgesic techniques. Unfortunately, these therapies are not without potential risks and side effects. These include nausea, vomiting, pruritus, urinary retention, constipation, respiratory depression, and sedation.
详细描述
One method used in this multimodal approach is the transversus abdominis plane block. This block, as first described by Rafi. in 2001, provides analgesia to the anterolateral abdominal wall. In 2007, McDonnell et al. further studied this technique in patients undergoing large-bowel resection. He discovered a reduction in postoperative pain and morphine consumption in the first 24 hours postoperatively, resulting in fewer opioid mediated side effects. In this same year, Hebbard et al. described the use of ultrasound guidance to provide real-time imaging of the muscle layers and needle placement to improve transversus abdominis plane block accuracy. In 2008, Hebbard. described the subcostal approach of transversus abdominis plane block, to target the nerves of the upper abdomen. Transversus abdominis plane blocks continue to be studied and developed as an effective method for providing analgesia for numerous types of transverses abdominis plane block duration is limited to effect of administered local anesthetics.The use of an infusion catheter to administer local anesthetics is an option to prolong the block's duration. Recently, adjuvant medications were added to local anesthetics to prolong the effect of transverses abdominis plane block .
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 65 Years 至 75 Years(Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •ASA physical status II-III,
- •scheduled for uncomplicated elective paraumbilical hernia repair.
排除标准
- •Patient refusal to participate in the study
- •Patients with coagulopathy or under anticoagulation therapy.
- •Infection near the site of needle insertion.
- •Body mass index > 40kg/m2
- •Patients with any neurological or neuromuscular disorder or history of seizures.
研究组 & 干预措施
Group B
Patients will receive Levobupivacaine 5%
干预措施: Levobupivacaine (Drug)
Group D
Patients will receive Levobupivacaine 5% + 1 µg/kg dexmedetomedine .
干预措施: Dexmedetomidine Injection [Precedex] (Drug)
Group F
Patients will receive Levobupivacaine 5% + 1µg/kg fentanyl
干预措施: fentanyl (Drug)
结局指标
主要结局
first analgesic request
时间窗: 24 hours
first time to call for analgesia
次要结局
未报告次要终点
研究者
Ghada Mohammed AboelFadl
principal investigator
Assiut University
