Effect of Ascorbic acid on occurrence and severity of post endodontic pain following root canal treatment on teeth with irreversible pulpitis. A triple-blind randomized placebo-controlled trial

Complete pain alleviation is a necessary precondition for endodontic therapy to be successful. Although microorganisms are commonly thought to be the primary cause of postoperative pain, pulpal or peri-radicular tissues may also be injured mechanically or chemically. Prostaglandins, leukotrienes, bradykinin, and serotonin are inflammatory mediators that activate sensitive nociceptors and cause postoperative endodontic pain. This can result in both peripheral and central mechanisms of hyperalgesia. Non-steroid anti-inflammatory medicines (NSAIDs), which are often used postoperative analgesics, have been linked to undesirable side effects, such as respiratory suppression, as well as other relatively mild issues, including nausea or vomiting. The L-enantiomer of ascorbate, or ascorbic acid, is commonly referred to as vitamin C and is a water-soluble antioxidant that may be found in a wide range of fruits and vegetables. There aren’t many research currently available assessing ascorbic acid’s impact on post endodontic pain. Therefore, the goal of this study is to clarify how well ascorbic acid works in situations with irreversible pulpitis to reduce immediate postoperative pain after root canal therapy.

Aim: evaluate the effect of ascorbic acid preoperatively on post endodontic pain reduction following endodontic treatment in irreversible pulpitis cases.

Objectives:

1)      Evaluate the effect of ascorbic acid on reduction of post endodontic pain at 4hrs, 8 hrs. 12 hrs, 24 hrs., and 48 hrs. Postoperatively in cases with preoperative irreversible pulpitis.

2)      Compare the effect of ascorbic acid with placebo in reduction of post endodontic pain.

Material and methods: This study will be a prospective parallel arm randomized triple -blind placebo-controlled trial. The study will be carried out in the Department Of Conservative Dentistry And Endodontics, Faculty of Dentistry, and Jamia Millia Islamia.60 patients (30 per group) with symptomatic irreversible pulpitis will be recruited for the study. The patients will be divided into two Groups. Group 1 will be given 500 mg ascorbic acid, one hour before the local anaesthesia. Group 2 patients will be given placebo multivitamin tablet one hour before local anaesthesia... Each patient willrecord their pain score on a heft parker visual analog scale before taking the medicine, at 4hrs, 8 hrs, 12 hrs, 24 hrs, and 48 hrs postoperatively.